| pubmed-article:1944268 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C0021759 | lld:lifeskim |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C0024297 | lld:lifeskim |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C1522138 | lld:lifeskim |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:1944268 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:1944268 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:1944268 | pubmed:dateCreated | 1991-12-24 | lld:pubmed |
| pubmed-article:1944268 | pubmed:abstractText | The region extending from -40 to -54 of the 5'-flanking region of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene shows homology to sequences found in the 5'-flanking regions of other cytokine genes, those encoding interleukin-4 (IL-4), IL-5, and granulocyte colony-stimulating factor (G-CSF). This sequence element is referred to as conserved lymphokine element 0 (CLE0). Saturation mutagenesis of the CLE0 element indicates that in addition to the previously mapped region between -73 and -91 (CLE2+ GC box), the CLE0 element is necessary for induction of the mouse GM-CSF gene by phorbol myristate acetate/Ca ionophore (A23187) stimulation in T cells. The presence of the CLE0 element is necessary to observe stimulation of the transcription activity of the mouse GM-CSF promoter in vitro. Mobility shift assays revealed that this region forms an inducible DNA-protein complex, NF-CLE0, which consists of two complexes of similar mobility, NF-CLE0a and NF-CLE0b. NF-CLE0a and NF-CLE0b recognize the 3' half and 5' half of the CLE0 element, respectively, with an overlapping region recognized by both proteins. The recognition sequence of NF-CLE0a corresponds to the region required for induction by phorbol myristate acetate/A23187, while the recognition sequence of NF-CLE0b contains bases that have inhibitory activity.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
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| pubmed-article:1944268 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1944268 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1944268 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1944268 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1944268 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:1944268 | pubmed:author | pubmed-author:AraiKK | lld:pubmed |
| pubmed-article:1944268 | pubmed:author | pubmed-author:AraiNN | lld:pubmed |
| pubmed-article:1944268 | pubmed:author | pubmed-author:ShlomaiJJ | lld:pubmed |
| pubmed-article:1944268 | pubmed:author | pubmed-author:MiyatakeSS | lld:pubmed |
| pubmed-article:1944268 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1944268 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:1944268 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1944268 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1944268 | pubmed:pagination | 5894-901 | lld:pubmed |
| pubmed-article:1944268 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1944268 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1944268 | pubmed:articleTitle | Characterization of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter: nuclear factors that interact with an element shared by three lymphokine genes--those for GM-CSF, interleukin-4 (IL-4), and IL-5. | lld:pubmed |
| pubmed-article:1944268 | pubmed:affiliation | Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304-1104. | lld:pubmed |
| pubmed-article:1944268 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1944268 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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