| pubmed-article:19442044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19442044 | lifeskim:mentions | umls-concept:C0015689 | lld:lifeskim |
| pubmed-article:19442044 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:19442044 | lifeskim:mentions | umls-concept:C1442792 | lld:lifeskim |
| pubmed-article:19442044 | lifeskim:mentions | umls-concept:C0016884 | lld:lifeskim |
| pubmed-article:19442044 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19442044 | pubmed:dateCreated | 2009-5-15 | lld:pubmed |
| pubmed-article:19442044 | pubmed:abstractText | Omega-3 fatty acids (omega3-FA) were shown to attenuate growth and induce apoptosis in a variety of human cancer cell lines derived from colonic, pancreatic, prostate, and breast cancer. In addition, recent findings indicate that omega3-FA act synergistically with chemotherapeutic agents and may also be used to enhance tumour radiosensitivity. The mechanisms underlying the anti-tumour effects of omega3-FA are complex. Incorporation of omega3-FA in biological membranes alters the profile of lipid mediators generated during inflammatory reactions. Furthermore, omega3-FA act as ligands of nuclear peroxisome proliferator-activated receptors that attenuate transcription of NF-kappaB-dependent genes. Thereby, the cyclooxygenase-2/prostaglandin E(2)-dependent production of pro-angiogenic vascular endothelial growth factor and levels of anti-apoptotic bcl-2 and bcl-X(L) are decreased. Eicosanoid-independent pro-apoptotic pathways include enhanced lipid peroxidation, modulation of mitochondrial calcium homeostasis and enhanced production of reactive oxygen species as well as activation of p53. This review article will give a comprehensive overview over the pleiotropic actions of omega3-FA and will discuss the potential of omega3-FA and derivatives like conjugated eicosapentaenoic acid as important nutritional adjuvant therapeutics in the management of various human cancer diseases and the impact of nutritional omega-3 FA on cancer prevention. | lld:pubmed |
| pubmed-article:19442044 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19442044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19442044 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19442044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19442044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19442044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19442044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19442044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19442044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19442044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19442044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19442044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19442044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19442044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19442044 | pubmed:month | May | lld:pubmed |
| pubmed-article:19442044 | pubmed:issn | 1875-5992 | lld:pubmed |
| pubmed-article:19442044 | pubmed:author | pubmed-author:HellerAxel... | lld:pubmed |
| pubmed-article:19442044 | pubmed:author | pubmed-author:WendelMartina... | lld:pubmed |
| pubmed-article:19442044 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19442044 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:19442044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19442044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19442044 | pubmed:pagination | 457-70 | lld:pubmed |
| pubmed-article:19442044 | pubmed:meshHeading | pubmed-meshheading:19442044... | lld:pubmed |
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| pubmed-article:19442044 | pubmed:meshHeading | pubmed-meshheading:19442044... | lld:pubmed |
| pubmed-article:19442044 | pubmed:meshHeading | pubmed-meshheading:19442044... | lld:pubmed |
| pubmed-article:19442044 | pubmed:meshHeading | pubmed-meshheading:19442044... | lld:pubmed |
| pubmed-article:19442044 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19442044 | pubmed:articleTitle | Anticancer actions of omega-3 fatty acids--current state and future perspectives. | lld:pubmed |
| pubmed-article:19442044 | pubmed:affiliation | Department of Physiology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany. MartinaWendel@gmx.de | lld:pubmed |
| pubmed-article:19442044 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19442044 | pubmed:publicationType | Review | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19442044 | lld:pubmed |
