| pubmed-article:19439659 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19439659 | lifeskim:mentions | umls-concept:C0043457 | lld:lifeskim |
| pubmed-article:19439659 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:19439659 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:19439659 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19439659 | lifeskim:mentions | umls-concept:C1820224 | lld:lifeskim |
| pubmed-article:19439659 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:19439659 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:19439659 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:19439659 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:19439659 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:19439659 | pubmed:dateCreated | 2009-5-27 | lld:pubmed |
| pubmed-article:19439659 | pubmed:abstractText | Spatial organization of cells and their appendages is controlled by the planar cell polarity pathway, a signaling cascade initiated by the protocadherin Fat in Drosophila. Vertebrates express 4 Fat molecules, Fat1-4. We found that depletion of Fat1 caused cyst formation in the zebrafish pronephros. Knockdown of the PDZ domain containing the adaptor protein Scribble intensified the cyst-promoting phenotype of Fat1 depletion, suggesting that Fat1 and Scribble act in overlapping signaling cascades during zebrafish pronephros development. Supporting the genetic interaction with Fat1, Scribble recognized the PDZ-binding site of Fat1. Depletion of Yes-associated protein 1 (YAP1), a transcriptional co-activator inhibited by Hippo signaling, ameliorated the cyst formation in Fat1-deficient zebrafish, whereas Scribble inhibited the YAP1-induced cyst formation. Thus, reduced Hippo signaling and subsequent YAP1 disinhibition seem to play a role in the development of pronephric cysts after depletion of Fat1 or Scribble. We hypothesize that Hippo signaling is required for normal pronephros development in zebrafish and that Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates. | lld:pubmed |
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| pubmed-article:19439659 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19439659 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19439659 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19439659 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19439659 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19439659 | pubmed:month | May | lld:pubmed |
| pubmed-article:19439659 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:WalzGerdG | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:MlodzikMarekM | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:EnglertChrist... | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:SimonsMatiasM | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:MoellerMarcus... | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:KimEmilyE | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:KuehnE... | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:HuberTobias... | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:BolligFrankF | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:HartlebenBjör... | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:SchäferTobias... | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:Kramer-Zucker... | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:PuetzMichaelM | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:BoehlkeChrist... | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:RamachandranH... | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:EngelChristin... | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:CourbardJean-... | lld:pubmed |
| pubmed-article:19439659 | pubmed:author | pubmed-author:SkouloudakiKa... | lld:pubmed |
| pubmed-article:19439659 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19439659 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:19439659 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19439659 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19439659 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19439659 | pubmed:pagination | 8579-84 | lld:pubmed |
| pubmed-article:19439659 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
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| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:meshHeading | pubmed-meshheading:19439659... | lld:pubmed |
| pubmed-article:19439659 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19439659 | pubmed:articleTitle | Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. | lld:pubmed |
