| pubmed-article:19436136 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19436136 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:19436136 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:19436136 | lifeskim:mentions | umls-concept:C0042878 | lld:lifeskim |
| pubmed-article:19436136 | lifeskim:mentions | umls-concept:C0042333 | lld:lifeskim |
| pubmed-article:19436136 | lifeskim:mentions | umls-concept:C0449438 | lld:lifeskim |
| pubmed-article:19436136 | lifeskim:mentions | umls-concept:C0061495 | lld:lifeskim |
| pubmed-article:19436136 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:19436136 | lifeskim:mentions | umls-concept:C0079809 | lld:lifeskim |
| pubmed-article:19436136 | lifeskim:mentions | umls-concept:C0148517 | lld:lifeskim |
| pubmed-article:19436136 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19436136 | pubmed:dateCreated | 2009-5-13 | lld:pubmed |
| pubmed-article:19436136 | pubmed:abstractText | Genetic factors, specifically the VKORC1 and GGCX genes, have been shown to contribute to the interindividual variability in response to the vitamin K-antagonist, warfarin, which influences the dose required to achieve the desired anticoagulation response. These differences in warfarin sensitivity may be explained by differences in vitamin K status. Men and women (n=416, 60-80 y), primarily of European descent, were genotyped for common polymorphisms in VKORC1 and GGCX. Cross-sectional associations exist between polymorphisms and biochemical markers of vitamin K [plasma phylloquinone, percent undercarboxylated osteocalcin (%ucOC)]. VKORC1 rs8050894 GG homozygotes had significantly higher cross-sectional measures of plasma phylloquinone than carriers of the CG or CC genotypes (plasma phylloquinone geometric means: GG 0.874+/-0.092 versus CG/CC 0.598+/- 0.044; p=0.020), whereas carriers of VKORC1 rs7294 AA or AG had significantly lower plasma phylloquinone concentrations compared to GG homozygotes (plasma phylloquinone geometric means: 0.579+/-0.045 versus 0.762+/-0.057; p=0.035). Cross-sectional analyses also revealed that heterozygous carriers of GGCX rs10187424 and rs7568458 had significantly lower %ucOC relative to either homozygous group. Polymorphisms in genes encoding enzymes involved in vitamin K metabolism may modulate plasma concentrations of phylloquionone and percent carboxylation of osteocalcin. | lld:pubmed |
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| pubmed-article:19436136 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19436136 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19436136 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19436136 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19436136 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19436136 | pubmed:issn | 1881-7742 | lld:pubmed |
| pubmed-article:19436136 | pubmed:author | pubmed-author:OrdovasJose... | lld:pubmed |
| pubmed-article:19436136 | pubmed:author | pubmed-author:Dawson-Hughes... | lld:pubmed |
| pubmed-article:19436136 | pubmed:author | pubmed-author:BoothSarah... | lld:pubmed |
| pubmed-article:19436136 | pubmed:author | pubmed-author:PeterIngaI | lld:pubmed |
| pubmed-article:19436136 | pubmed:author | pubmed-author:CrosierMichae... | lld:pubmed |
| pubmed-article:19436136 | pubmed:author | pubmed-author:BennettGraceG | lld:pubmed |
| pubmed-article:19436136 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19436136 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:19436136 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19436136 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19436136 | pubmed:pagination | 112-9 | lld:pubmed |
| pubmed-article:19436136 | pubmed:dateRevised | 2010-9-24 | lld:pubmed |
| pubmed-article:19436136 | pubmed:meshHeading | pubmed-meshheading:19436136... | lld:pubmed |
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| pubmed-article:19436136 | pubmed:meshHeading | pubmed-meshheading:19436136... | lld:pubmed |
| pubmed-article:19436136 | pubmed:meshHeading | pubmed-meshheading:19436136... | lld:pubmed |
| pubmed-article:19436136 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19436136 | pubmed:articleTitle | Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status. | lld:pubmed |
| pubmed-article:19436136 | pubmed:affiliation | USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. | lld:pubmed |
| pubmed-article:19436136 | pubmed:publicationType | Journal Article | lld:pubmed |
