| pubmed-article:19436054 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19436054 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:19436054 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:19436054 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19436054 | lifeskim:mentions | umls-concept:C0391845 | lld:lifeskim |
| pubmed-article:19436054 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:19436054 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:19436054 | lifeskim:mentions | umls-concept:C0243102 | lld:lifeskim |
| pubmed-article:19436054 | lifeskim:mentions | umls-concept:C0585064 | lld:lifeskim |
| pubmed-article:19436054 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19436054 | pubmed:dateCreated | 2009-7-3 | lld:pubmed |
| pubmed-article:19436054 | pubmed:abstractText | Dendritic cells (DCs) play a key role in the pathogenesis of HIV infection. HIV interacts with these cells through 2 pathways in 2 temporal phases, initially via endocytosis and then via de novo replication. Here the transcriptional response of human DCs to HIV-1 was studied in these phases and at different stages of the virus replication cycle using purified HIV-1 envelope proteins, and inactivated and viable HIV-1. No differential gene expression was detected in response to envelope. However, more than 100 genes were differentially expressed in response to entry of viable and inactivated HIV-1 in the first phase. A completely different set of genes was differentially expressed in the second phase, predominantly in response to viable HIV-1, including up-regulation of immune regulation genes, whereas genes encoding lysosomal enzymes were down-regulated. Cathepsins B, C, S, and Z RNA and protein decreased, whereas cathepsin L was increased, probably reflecting a concomitant decrease in cystatin C. The net effect was markedly diminished cathepsin activity likely to result in enhanced HIV-1 survival and transfer to contacting T lymphocytes but decreased HIV-1 antigen processing and presentation to these T cells. | lld:pubmed |
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| pubmed-article:19436054 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19436054 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19436054 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19436054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19436054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19436054 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19436054 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19436054 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:19436054 | pubmed:author | pubmed-author:DriessenChris... | lld:pubmed |
| pubmed-article:19436054 | pubmed:author | pubmed-author:CunninghamAnt... | lld:pubmed |
| pubmed-article:19436054 | pubmed:author | pubmed-author:NasrNajlaN | lld:pubmed |
| pubmed-article:19436054 | pubmed:author | pubmed-author:BythKarenK | lld:pubmed |
| pubmed-article:19436054 | pubmed:author | pubmed-author:SlobedmanBarr... | lld:pubmed |
| pubmed-article:19436054 | pubmed:author | pubmed-author:TurvilleStuar... | lld:pubmed |
| pubmed-article:19436054 | pubmed:author | pubmed-author:KrausMarianne... | lld:pubmed |
| pubmed-article:19436054 | pubmed:author | pubmed-author:HarmanAndrew... | lld:pubmed |
| pubmed-article:19436054 | pubmed:author | pubmed-author:ByeChris RCR | lld:pubmed |
| pubmed-article:19436054 | pubmed:author | pubmed-author:TangOwenO | lld:pubmed |
| pubmed-article:19436054 | pubmed:author | pubmed-author:MercierSarah... | lld:pubmed |
| pubmed-article:19436054 | pubmed:author | pubmed-author:SternJosh LJL | lld:pubmed |
| pubmed-article:19436054 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19436054 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:19436054 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:19436054 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19436054 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19436054 | pubmed:pagination | 85-94 | lld:pubmed |
| pubmed-article:19436054 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
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