| pubmed-article:19435911 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19435911 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19435911 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:19435911 | lifeskim:mentions | umls-concept:C0242957 | lld:lifeskim |
| pubmed-article:19435911 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:19435911 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:19435911 | lifeskim:mentions | umls-concept:C0908145 | lld:lifeskim |
| pubmed-article:19435911 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:19435911 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:19435911 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:19435911 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:19435911 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:19435911 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:19435911 | pubmed:dateCreated | 2009-6-2 | lld:pubmed |
| pubmed-article:19435911 | pubmed:abstractText | Protein tyrosine phosphatase (PTP) 1B plays a major role in inhibiting signaling from the insulin and leptin receptors. Recently, PTP1B was found to have an unexpected positive role in ErbB2 signaling in a mouse model of breast cancer, but the mechanism underlying this effect has been unclear. Using human breast epithelial cells grown in a three-dimensional matrix, we found that PTP1B, but not the closely related enzyme T-cell PTP, is required for ErbB2 transformation in vitro. Activation of ErbB2, but not ErbB1, increases PTP1B expression, and increased expression of PTP1B activates Src and induces a Src-dependent transformed phenotype. These findings identify a molecular mechanism by which PTP1B links an important oncogenic receptor tyrosine kinase to signaling pathways that promote aberrant cell division and survival in human breast epithelial cells. | lld:pubmed |
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| pubmed-article:19435911 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19435911 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19435911 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19435911 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19435911 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19435911 | pubmed:issn | 1538-7445 | lld:pubmed |
| pubmed-article:19435911 | pubmed:author | pubmed-author:ZhangZhong-Yi... | lld:pubmed |
| pubmed-article:19435911 | pubmed:author | pubmed-author:ChernoffJonat... | lld:pubmed |
| pubmed-article:19435911 | pubmed:author | pubmed-author:EthierStephen... | lld:pubmed |
| pubmed-article:19435911 | pubmed:author | pubmed-author:Villamar-Cruz... | lld:pubmed |
| pubmed-article:19435911 | pubmed:author | pubmed-author:YipShu-ChinSC | lld:pubmed |
| pubmed-article:19435911 | pubmed:author | pubmed-author:SahaSayantiS | lld:pubmed |
| pubmed-article:19435911 | pubmed:author | pubmed-author:Arias-RomeroL... | lld:pubmed |
| pubmed-article:19435911 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19435911 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19435911 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:19435911 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19435911 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19435911 | pubmed:pagination | 4582-8 | lld:pubmed |
| pubmed-article:19435911 | pubmed:dateRevised | 2011-6-10 | lld:pubmed |
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| pubmed-article:19435911 | pubmed:meshHeading | pubmed-meshheading:19435911... | lld:pubmed |
| pubmed-article:19435911 | pubmed:meshHeading | pubmed-meshheading:19435911... | lld:pubmed |
| pubmed-article:19435911 | pubmed:meshHeading | pubmed-meshheading:19435911... | lld:pubmed |
| pubmed-article:19435911 | pubmed:meshHeading | pubmed-meshheading:19435911... | lld:pubmed |
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| pubmed-article:19435911 | pubmed:meshHeading | pubmed-meshheading:19435911... | lld:pubmed |
| pubmed-article:19435911 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19435911 | pubmed:articleTitle | Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. | lld:pubmed |
| pubmed-article:19435911 | pubmed:affiliation | Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA. | lld:pubmed |
| pubmed-article:19435911 | pubmed:publicationType | Journal Article | lld:pubmed |
