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pubmed-article:19432956pubmed:abstractTextParagangliomas of the head and neck are highly vascular and usually clinically benign tumors arising in the paraganglia of the autonomic nervous system. A significant number of cases (10-50%) are proven to be familial. Multiple genes encoding subunits of the mitochondrial succinate-dehydrogenase (SDH) complex are associated with hereditary paraganglioma: SDHB, SDHC and SDHD. Furthermore, a hereditary paraganglioma family has been identified with linkage to the PGL2 locus on 11q13. No SDH genes are known to be located in the 11q13 region, and the exact gene defect has not yet been identified in this family.lld:pubmed
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pubmed-article:19432956pubmed:authorpubmed-author:CornelisseCee...lld:pubmed
pubmed-article:19432956pubmed:authorpubmed-author:DevileePeterPlld:pubmed
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pubmed-article:19432956pubmed:authorpubmed-author:GoemanJelle...lld:pubmed
pubmed-article:19432956pubmed:authorpubmed-author:HensenErik...lld:pubmed
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pubmed-article:19432956pubmed:year2009lld:pubmed
pubmed-article:19432956pubmed:articleTitleSimilar gene expression profiles of sporadic, PGL2-, and SDHD-linked paragangliomas suggest a common pathway to tumorigenesis.lld:pubmed
pubmed-article:19432956pubmed:affiliationDepartment of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, the Netherlands. e.f.hensen@lumc.nllld:pubmed
pubmed-article:19432956pubmed:publicationTypeJournal Articlelld:pubmed