| pubmed-article:19430615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19430615 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:19430615 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19430615 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19430615 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:19430615 | lifeskim:mentions | umls-concept:C0026237 | lld:lifeskim |
| pubmed-article:19430615 | lifeskim:mentions | umls-concept:C0912024 | lld:lifeskim |
| pubmed-article:19430615 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19430615 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19430615 | pubmed:dateCreated | 2009-5-11 | lld:pubmed |
| pubmed-article:19430615 | pubmed:abstractText | In this study, we investigated the mechanistic role of the caspase cascade in extrinsic and intrinsic apoptosis induced by apigenin, which has been targeted as a candidate in the development of noncytotoxic anticancer medicines. Treatment with apigenin (1-100 microM) significantly inhibited the proliferation of MDA-MB-453 human breast cancer cells in a dose- and time-dependent manner with IC(50) values of 59.44 and 35.15 microM at 24 and 72 h, respectively. This inhibition resulted in the induction of apoptosis and the release of cytochrome c in cells exposed to apigenin at its 72 h IC(50). Subsequently, caspase-9, which acts in mitochondria-mediated apoptosis, was cleaved by apigenin. In addition, apigenin activated caspase-3, which functions downstream of caspase-9. The apigenin-induced activation of caspase-3 was accompanied by the cleavage of capases-6, -7, and -8. These results are supported by evidence showing that the activity patterns of caspases-3, -8, and -9 were similar. The present study supports the hypothesis that apigenin-induced apoptosis involves the activation of both the intrinsic and extrinsic apoptotic pathways. | lld:pubmed |
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| pubmed-article:19430615 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19430615 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19430615 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:19430615 | pubmed:month | May | lld:pubmed |
| pubmed-article:19430615 | pubmed:issn | 0912-0009 | lld:pubmed |
| pubmed-article:19430615 | pubmed:author | pubmed-author:ChoiEun... | lld:pubmed |
| pubmed-article:19430615 | pubmed:author | pubmed-author:KimGun-HeeGH | lld:pubmed |
| pubmed-article:19430615 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19430615 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:19430615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19430615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19430615 | pubmed:pagination | 260-5 | lld:pubmed |
| pubmed-article:19430615 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19430615 | pubmed:articleTitle | Apigenin Induces Apoptosis through a Mitochondria/Caspase-Pathway in Human Breast Cancer MDA-MB-453 Cells. | lld:pubmed |
| pubmed-article:19430615 | pubmed:affiliation | Plant Resources Research Institute, Duksung Women's University, 419 Ssangmun-dong, Tobong-ku, Seoul 132-714, South Korea. | lld:pubmed |
| pubmed-article:19430615 | pubmed:publicationType | Journal Article | lld:pubmed |
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