| pubmed-article:19429787 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19429787 | lifeskim:mentions | umls-concept:C0237868 | lld:lifeskim |
| pubmed-article:19429787 | lifeskim:mentions | umls-concept:C0178784 | lld:lifeskim |
| pubmed-article:19429787 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:19429787 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:19429787 | lifeskim:mentions | umls-concept:C0036679 | lld:lifeskim |
| pubmed-article:19429787 | lifeskim:mentions | umls-concept:C0599896 | lld:lifeskim |
| pubmed-article:19429787 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19429787 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:19429787 | pubmed:dateCreated | 2009-5-11 | lld:pubmed |
| pubmed-article:19429787 | pubmed:abstractText | Cell separation, or abscission, is a highly specialized process in plants that facilitates remodeling of their architecture and reproductive success. Because few genes are known to be essential for organ abscission, we conducted a screen for mutations that alter floral organ shedding in Arabidopsis. Nine recessive mutations that block shedding were found to disrupt the function of an ADP-ribosylation factor-GTPase-activating protein (ARF-GAP) we have named NEVERSHED (NEV). As predicted by its homology to the yeast Age2 ARF-GAP and transcriptional profile, NEV influences other aspects of plant development, including fruit growth. Co-localization experiments carried out with NEV-specific antiserum and a set of plant endomembrane markers revealed that NEV localizes to the trans-Golgi network and endosomes in Arabidopsis root epidermal cells. Interestingly, transmission electron micrographs of abscission zone regions from wild-type and nev flowers reveal defects in the structure of the Golgi apparatus and extensive accumulation of vesicles adjacent to the cell walls. Our results suggest that NEV ARF-GAP activity at the trans-Golgi network and distinct endosomal compartments is required for the proper trafficking of cargo molecules required for cell separation. | lld:pubmed |
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| pubmed-article:19429787 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19429787 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19429787 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19429787 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19429787 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19429787 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19429787 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19429787 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:19429787 | pubmed:author | pubmed-author:ChoryJoanneJ | lld:pubmed |
