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pubmed-article:19424988pubmed:dateCreated2009-6-24lld:pubmed
pubmed-article:19424988pubmed:abstractTextControl of inflammation is essential for the clinical management of many common human diseases. However, there are few generally applicable strategies to convert an abnormal intracellular signal into a gene expression that leads to normalization of the intracellular environment. Recently, we proposed a novel strategy termed D-RECS (i.e. drug or gene delivery system responding to cellular signals) to convert an intracellular signal to transgene expression. In the present study, we applied this concept to inflammatory cells using Ikappa-B kinase as a signal molecule that triggers the gene expression.lld:pubmed
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pubmed-article:19424988pubmed:issn1521-2254lld:pubmed
pubmed-article:19424988pubmed:authorpubmed-author:MoriTakeshiTlld:pubmed
pubmed-article:19424988pubmed:authorpubmed-author:NakashimaHide...lld:pubmed
pubmed-article:19424988pubmed:authorpubmed-author:KawamuraKenji...lld:pubmed
pubmed-article:19424988pubmed:authorpubmed-author:NiidomeTakuro...lld:pubmed
pubmed-article:19424988pubmed:authorpubmed-author:ShojiYokoYlld:pubmed
pubmed-article:19424988pubmed:authorpubmed-author:KangJeong-Hun...lld:pubmed
pubmed-article:19424988pubmed:authorpubmed-author:KatayamaYoshi...lld:pubmed
pubmed-article:19424988pubmed:authorpubmed-author:TsuchiyaAkira...lld:pubmed
pubmed-article:19424988pubmed:authorpubmed-author:OishiJunJlld:pubmed
pubmed-article:19424988pubmed:authorpubmed-author:AsaiDaisukeDlld:pubmed
pubmed-article:19424988pubmed:copyrightInfo2009 John Wiley & Sons, Ltd.lld:pubmed
pubmed-article:19424988pubmed:issnTypeElectroniclld:pubmed
pubmed-article:19424988pubmed:volume11lld:pubmed
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pubmed-article:19424988pubmed:authorsCompleteYlld:pubmed
pubmed-article:19424988pubmed:pagination624-32lld:pubmed
pubmed-article:19424988pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:19424988pubmed:year2009lld:pubmed
pubmed-article:19424988pubmed:articleTitleInflammatory cell-specific transgene expression system responding to Ikappa-B kinase beta activation.lld:pubmed
pubmed-article:19424988pubmed:affiliationDepartment of Microbiology, St Marianna University School of Medicine, Kawasaki, Japan. asai@marianna-u.ac.jplld:pubmed
pubmed-article:19424988pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19424988pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:19424988pubmed:publicationTypeEvaluation Studieslld:pubmed