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pubmed-article:19424017pubmed:abstractTextData have recently pointed to a possible regulatory function of T-cell immunoglobulin mucin protein 1 (TIM-1) during the alloimmune response. Cross-linking TIM-1 onto CD4+ T cells intensifies proinflammatory cytopathic allogeneic response and inhibits the development of natural and inducible regulatory T cells. The TIM-1 pathway might thus be a potential hurdle to the induction of tolerance in transplantation. Not unexpectedly, blocking the TIM-1 pathway is now emerging as a successful strategy to promote experimental peripheral tolerance.lld:pubmed
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pubmed-article:19424017pubmed:articleTitleTIM-1: a new player in transplant immunity.lld:pubmed
pubmed-article:19424017pubmed:affiliationThe Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.lld:pubmed
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