| pubmed-article:19423340 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19423340 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:19423340 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:19423340 | lifeskim:mentions | umls-concept:C0005290 | lld:lifeskim |
| pubmed-article:19423340 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:19423340 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19423340 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19423340 | lifeskim:mentions | umls-concept:C1656349 | lld:lifeskim |
| pubmed-article:19423340 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:19423340 | pubmed:dateCreated | 2009-5-29 | lld:pubmed |
| pubmed-article:19423340 | pubmed:abstractText | Novel C-seco-taxoids were synthesized from 10-deacetylbaccatin III and their potencies evaluated against drug-sensitive and drug-resistant cancer cell lines. The drug-resistant cell lines include ovarian cancer cell lines resistant to cisplatin, topotecan, adriamycin and paclitaxel overexpressing class III beta-tubulin, A2780TC1 and A2780TC3. The last two cell lines were selected through chronic exposure of A2780wt to paclitaxel and Pgp blocker cyclosporine. All novel C-seco-taxoids exhibited remarkable potency against A2780TC1 and A2780TC3 cell lines, and no cross resistance to cisplatin- and topotecan-resistant cell lines, A2780CIS and A2780TOP. Four of those C-seco-taxoids exhibit much higher activities than IDN5390 against paclitaxel-resistant cell lines, A2780ADR, A2780TC1 and A2780TC3. SB-CST-10202 possesses the best all-round high potencies across different drug-resistant cell lines. Molecular modeling studies, including molecular dynamics simulations, on the drug-protein complexes of class I and III beta-tubulins were performed to identify possible cause of the remarkable potency of these C-seco-taxoids against paclitaxel-resistant cell lines overexpressing class III beta-tubulin. | lld:pubmed |
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| pubmed-article:19423340 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19423340 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19423340 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19423340 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19423340 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19423340 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:19423340 | pubmed:author | pubmed-author:OjimaIwaoI | lld:pubmed |
| pubmed-article:19423340 | pubmed:author | pubmed-author:FerliniCristi... | lld:pubmed |
| pubmed-article:19423340 | pubmed:author | pubmed-author:BombardelliEz... | lld:pubmed |
| pubmed-article:19423340 | pubmed:author | pubmed-author:SunLiangL | lld:pubmed |
| pubmed-article:19423340 | pubmed:author | pubmed-author:WuXinyuanX | lld:pubmed |
| pubmed-article:19423340 | pubmed:author | pubmed-author:FontanaGabrie... | lld:pubmed |
| pubmed-article:19423340 | pubmed:author | pubmed-author:PepeAntonella... | lld:pubmed |
| pubmed-article:19423340 | pubmed:author | pubmed-author:ZanardiIlaria... | lld:pubmed |
| pubmed-article:19423340 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19423340 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19423340 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:19423340 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19423340 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19423340 | pubmed:pagination | 3300-4 | lld:pubmed |
| pubmed-article:19423340 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:19423340 | pubmed:meshHeading | pubmed-meshheading:19423340... | lld:pubmed |
| pubmed-article:19423340 | pubmed:meshHeading | pubmed-meshheading:19423340... | lld:pubmed |
| pubmed-article:19423340 | pubmed:meshHeading | pubmed-meshheading:19423340... | lld:pubmed |
| pubmed-article:19423340 | pubmed:meshHeading | pubmed-meshheading:19423340... | lld:pubmed |
| pubmed-article:19423340 | pubmed:meshHeading | pubmed-meshheading:19423340... | lld:pubmed |
| pubmed-article:19423340 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19423340 | pubmed:articleTitle | Novel C-seco-taxoids possessing high potency against paclitaxel-resistant cancer cell lines overexpressing class III beta-tubulin. | lld:pubmed |
| pubmed-article:19423340 | pubmed:affiliation | Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400, USA. | lld:pubmed |
| pubmed-article:19423340 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19423340 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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