| pubmed-article:19419141 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19419141 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:19419141 | lifeskim:mentions | umls-concept:C0051334 | lld:lifeskim |
| pubmed-article:19419141 | lifeskim:mentions | umls-concept:C1709060 | lld:lifeskim |
| pubmed-article:19419141 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19419141 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:19419141 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19419141 | lifeskim:mentions | umls-concept:C2717132 | lld:lifeskim |
| pubmed-article:19419141 | lifeskim:mentions | umls-concept:C2717133 | lld:lifeskim |
| pubmed-article:19419141 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:19419141 | pubmed:dateCreated | 2009-5-22 | lld:pubmed |
| pubmed-article:19419141 | pubmed:abstractText | The discovery of a series of pyrrole-sulfonamides as positive allosteric modulators (PAM) of alpha7 nAChRs is described. Optimization of this series led to the identification of 19 (A-867744), a novel type II PAM with good potency and selectivity. Compound 19 showed acceptable pharmacokinetic profile across species and brain levels sufficient to modulate alpha7 nAChRs. In a rodent model of sensory gating, 19 normalized gating deficits. These results suggest that 19 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs. | lld:pubmed |
| pubmed-article:19419141 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19419141 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19419141 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19419141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19419141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19419141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19419141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19419141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19419141 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19419141 | pubmed:month | May | lld:pubmed |
| pubmed-article:19419141 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:MarshKennan... | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:BriggsClark... | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:Gopalakrishna... | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:FaghihRaminR | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:Gopalakrishna... | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:BunnelleWilli... | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:MalyszJohnJ | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:RadekRichard... | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:GfesserGregor... | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:CurtisMichael... | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:SarrisKathy... | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:WeenHildeH | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:GronlienJens... | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:RobbHolly MHM | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:WetterstrandC... | lld:pubmed |
| pubmed-article:19419141 | pubmed:author | pubmed-author:El-KouhenRach... | lld:pubmed |
| pubmed-article:19419141 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19419141 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:19419141 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:19419141 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19419141 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19419141 | pubmed:pagination | 3377-84 | lld:pubmed |
| pubmed-article:19419141 | pubmed:dateRevised | 2010-6-4 | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:meshHeading | pubmed-meshheading:19419141... | lld:pubmed |
| pubmed-article:19419141 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19419141 | pubmed:articleTitle | Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. | lld:pubmed |
| pubmed-article:19419141 | pubmed:affiliation | Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA. ramin.faghih@abbott.com | lld:pubmed |
| pubmed-article:19419141 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19419141 | lld:chembl |
