| pubmed-article:19416870 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19416870 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19416870 | lifeskim:mentions | umls-concept:C0206431 | lld:lifeskim |
| pubmed-article:19416870 | lifeskim:mentions | umls-concept:C0015219 | lld:lifeskim |
| pubmed-article:19416870 | lifeskim:mentions | umls-concept:C1415592 | lld:lifeskim |
| pubmed-article:19416870 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:19416870 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:19416870 | pubmed:dateCreated | 2009-5-21 | lld:pubmed |
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| pubmed-article:19416870 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19416870 | pubmed:abstractText | Several nonclassical major histocompatibilty antigens (class Ib molecules) have emerged as key players in the early immune response to pathogens or stress. Class Ib molecules activate subsets of T cells that mount effector responses before the adaptive immune system, and thus are called innate T cells. MR1 is a novel class Ib molecule with properties highly suggestive of its regulation of mucosal immunity. The Mr1 gene is evolutionarily conserved, is non-Mhc linked, and controls the development of mucosal-associated invariant T (MAIT) cells. MAIT cells preferentially reside in the gut, and their development is dependent on commensal microbiota. Although these properties suggest that MAIT cells function as innate T cells in the mucosa, this has been difficult to test, due to the (i) paucity of MAIT cells that display MR1-specific activation in vitro and (ii) lack of knowledge of whether or not MR1 presents antigen. Here we show that both mouse and human MAIT cells display a high level of cross-reactivity on mammalian MR1 orthologs, but with differences consistent with limited ligand discrimination. Furthermore, acid eluates from recombinant or cellular MR1 proteins enhance MAIT cell activation in an MR1-specific and cross-species manner. Our findings demonstrate that the presentation pathway of MR1 to MAIT cells is highly evolutionarily conserved. | lld:pubmed |
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| pubmed-article:19416870 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19416870 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19416870 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19416870 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19416870 | pubmed:month | May | lld:pubmed |
| pubmed-article:19416870 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19416870 | pubmed:author | pubmed-author:SoudaisClaire... | lld:pubmed |
| pubmed-article:19416870 | pubmed:author | pubmed-author:FremontDaved... | lld:pubmed |
| pubmed-article:19416870 | pubmed:author | pubmed-author:HansenTed HTH | lld:pubmed |
| pubmed-article:19416870 | pubmed:author | pubmed-author:HuangShouxion... | lld:pubmed |
| pubmed-article:19416870 | pubmed:author | pubmed-author:LantzOlivierO | lld:pubmed |
| pubmed-article:19416870 | pubmed:author | pubmed-author:YuLawrenceL | lld:pubmed |
| pubmed-article:19416870 | pubmed:author | pubmed-author:KimSojungS | lld:pubmed |
| pubmed-article:19416870 | pubmed:author | pubmed-author:MartinEmmanue... | lld:pubmed |
| pubmed-article:19416870 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19416870 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:19416870 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19416870 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19416870 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19416870 | pubmed:pagination | 8290-5 | lld:pubmed |
| pubmed-article:19416870 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:19416870 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19416870 | pubmed:articleTitle | MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution. | lld:pubmed |
| pubmed-article:19416870 | pubmed:affiliation | Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA. | lld:pubmed |
| pubmed-article:19416870 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19416870 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19416870 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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