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pubmed-article:19415410pubmed:abstractTextGlutathione peroxidase 1 (GPx1) is an antioxidant selenoenzyme that protects the cells against reactive oxygen species. Its activity depends on the concentration of selenium (Se) which is present in the active centre of the enzyme. The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the proline (Pro) to leucine (Leu) change at codon 198 is supposed to be functional. An in vitro study performed on human breast carcinoma cell line showed that GPx1Leu allele was associated with a lower responsiveness of the enzyme to Se added to the culture medium. Some authors observed a decrease in GPx1 activity associated with GPx1 Leu allele in humans; however, there were no findings on how GPx1 activity changes with Se concentration in individuals with different GPx1 genotypes.lld:pubmed
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pubmed-article:19415410pubmed:articleTitleAssociation between GPx1 Pro198Leu polymorphism, GPx1 activity and plasma selenium concentration in humans.lld:pubmed
pubmed-article:19415410pubmed:affiliationDepartment of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland. ewa@imp.lodz.pllld:pubmed
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