| pubmed-article:19412539 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19412539 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:19412539 | lifeskim:mentions | umls-concept:C0041327 | lld:lifeskim |
| pubmed-article:19412539 | lifeskim:mentions | umls-concept:C0041290 | lld:lifeskim |
| pubmed-article:19412539 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:19412539 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:19412539 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:19412539 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:19412539 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:19412539 | lifeskim:mentions | umls-concept:C0018591 | lld:lifeskim |
| pubmed-article:19412539 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19412539 | pubmed:dateCreated | 2009-5-4 | lld:pubmed |
| pubmed-article:19412539 | pubmed:abstractText | Evidence from genetic association and twin studies indicates that susceptibility to tuberculosis (TB) is under genetic control. One gene implicated in susceptibility to TB is that encoding interleukin-10 (IL10). In a group of 2010 Ghanaian patients with pulmonary TB and 2346 healthy controls exposed to Mycobacterium tuberculosis, among them 129 individuals lacking a tuberculin skin test (PPD) response, we genotyped four IL10 promoter variants at positions -2849 , -1082 , -819 , and -592 and reconstructed the haplotypes. The IL10 low-producer haplotype -2849A/-1082A/-819C/-592C, compared to the high-producer haplotype -2849G/-1082G/-819C/-592C, occurred less frequent among PPD-negative controls than among cases (OR 2.15, CI 1.3-3.6) and PPD-positive controls (OR 2.09, CI 1.2-3.5). Lower IL-10 plasma levels in homozygous -2849A/-1082A/-819C/-592C carriers, compared to homozygous -2849G/-1082G/-819C/-592C carriers, were confirmed by a IL-10 ELISA (p = 0.016). Although we did not observe differences between the TB patients and all controls, our results provide evidence that a group of individuals exposed to M. tuberculosis transmission is genetically distinct from healthy PPD positives and TB cases. In these PPD-negative individuals, higher IL-10 production appears to reflect IL-10-dependent suppression of adaptive immune responses and sustained long-term specific anergy. | lld:pubmed |
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| pubmed-article:19412539 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19412539 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19412539 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19412539 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19412539 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:19412539 | pubmed:author | pubmed-author:Rüsch-GerdesS... | lld:pubmed |
| pubmed-article:19412539 | pubmed:author | pubmed-author:BrattigNorber... | lld:pubmed |
| pubmed-article:19412539 | pubmed:author | pubmed-author:NiemannStefan... | lld:pubmed |
| pubmed-article:19412539 | pubmed:author | pubmed-author:HorstmannRolf... | lld:pubmed |
| pubmed-article:19412539 | pubmed:author | pubmed-author:MeyerChristia... | lld:pubmed |
| pubmed-article:19412539 | pubmed:author | pubmed-author:ThyeThorstenT | lld:pubmed |
| pubmed-article:19412539 | pubmed:author | pubmed-author:ChinbuahMarga... | lld:pubmed |
| pubmed-article:19412539 | pubmed:author | pubmed-author:BrowneEdmund... | lld:pubmed |
| pubmed-article:19412539 | pubmed:author | pubmed-author:Owusu-DaboEll... | lld:pubmed |
| pubmed-article:19412539 | pubmed:author | pubmed-author:OseiIvyI | lld:pubmed |
| pubmed-article:19412539 | pubmed:author | pubmed-author:GyapongJohnJ | lld:pubmed |
| pubmed-article:19412539 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19412539 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:19412539 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19412539 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19412539 | pubmed:pagination | e5420 | lld:pubmed |
| pubmed-article:19412539 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:19412539 | pubmed:meshHeading | pubmed-meshheading:19412539... | lld:pubmed |
| pubmed-article:19412539 | pubmed:meshHeading | pubmed-meshheading:19412539... | lld:pubmed |
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| pubmed-article:19412539 | pubmed:meshHeading | pubmed-meshheading:19412539... | lld:pubmed |
| pubmed-article:19412539 | pubmed:meshHeading | pubmed-meshheading:19412539... | lld:pubmed |
| pubmed-article:19412539 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19412539 | pubmed:articleTitle | IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB. | lld:pubmed |
| pubmed-article:19412539 | pubmed:affiliation | Bernhard Nocht Institute for Tropical Medicine, Department of Molecular Medicine, Hamburg, Germany. thye@bni-hamburg.de | lld:pubmed |
| pubmed-article:19412539 | pubmed:publicationType | Journal Article | lld:pubmed |
