| pubmed-article:1940791 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1940791 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:1940791 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:1940791 | lifeskim:mentions | umls-concept:C0020861 | lld:lifeskim |
| pubmed-article:1940791 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:1940791 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1940791 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1940791 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:1940791 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1940791 | pubmed:dateCreated | 1991-12-13 | lld:pubmed |
| pubmed-article:1940791 | pubmed:abstractText | Transfectants of mature B cell lines that bind phosphorylcholine were made in order to understand the role of the COOH terminus of the mu chain of membrane IgM (mIgM) in generation of antigen-specific signals. A chimeric receptor (I-A alpha tail) was constructed by replacing 40 amino acids from the mu COOH terminus with that of major histocompatibility complex class II I-A alpha chain. The effect of wild-type and chimeric tails were studied on representative immediate-early antigen-specific signals. The I-A alpha tail hybrid, but not the wild-type receptor, was defective in antigen-driven Ca2+ mobilization, although it could effectively endocytose ligand-receptor complexes. Signal(s) transduced through the wild-type receptor led to transient induction of selected immediate-early gene messages (Egr-1, c-fos, Jun) above basal levels. However, the signal(s) generated after crosslinking of the I-A alpha tail receptor either showed no effect (c-fos) or actually repressed basal level expression of Egr-1 and Jun. Thus, we have established that receptor-mediated endocytosis can be distinguished from other early events associated with B cell activation, based on their differential dependence upon the structural fidelity of the COOH-terminal sequence of mIgM. | lld:pubmed |
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| pubmed-article:1940791 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1940791 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1940791 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1940791 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1940791 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1940791 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:1940791 | pubmed:author | pubmed-author:TuckerP WPW | lld:pubmed |
| pubmed-article:1940791 | pubmed:author | pubmed-author:BankertR BRB | lld:pubmed |
| pubmed-article:1940791 | pubmed:author | pubmed-author:NakaiCC | lld:pubmed |
| pubmed-article:1940791 | pubmed:author | pubmed-author:ParikhV SVS | lld:pubmed |
| pubmed-article:1940791 | pubmed:author | pubmed-author:YokotaS JSJ | lld:pubmed |
| pubmed-article:1940791 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1940791 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1940791 | pubmed:volume | 174 | lld:pubmed |
| pubmed-article:1940791 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1940791 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1940791 | pubmed:pagination | 1103-9 | lld:pubmed |
| pubmed-article:1940791 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1940791 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1940791 | pubmed:articleTitle | COOH terminus of membrane IgM is essential for an antigen-specific induction of some but not all early activation events in mature B cells. | lld:pubmed |
| pubmed-article:1940791 | pubmed:affiliation | Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235. | lld:pubmed |
