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pubmed-article:19405129pubmed:abstractTextLandmark-based high-dimensional diffeomorphic maps of the hippocampus (although accurate) is highly-dependent on rater's anatomic knowledge of the hippocampus in the magnetic resonance images. It is therefore vulnerable to rater drift and errors if substantial amount of effort is not spent on quality assurance, training, and re-training. A fully-automated, FreeSurfer-initialized large-deformation diffeomorphic metric mapping procedure of small brain substructures, including the hippocampus, has been previously developed and validated in small samples. In this report, we demonstrate that this fully-automated pipeline can be used in place of the landmark-based procedure in a large-sample clinical study to produce similar statistical outcomes. Some direct comparisons of the two procedures are also presented.lld:pubmed
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pubmed-article:19405129pubmed:authorpubmed-author:MorrisJohn...lld:pubmed
pubmed-article:19405129pubmed:authorpubmed-author:WangLeiLlld:pubmed
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pubmed-article:19405129pubmed:copyrightInfo2009 Wiley-Liss, Inc.lld:pubmed
pubmed-article:19405129pubmed:issnTypeElectroniclld:pubmed
pubmed-article:19405129pubmed:volume19lld:pubmed
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pubmed-article:19405129pubmed:dateRevised2011-4-25lld:pubmed
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pubmed-article:19405129pubmed:articleTitleFully-automated, multi-stage hippocampus mapping in very mild Alzheimer disease.lld:pubmed
pubmed-article:19405129pubmed:affiliationDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. leiwang1@northwestern.edulld:pubmed
pubmed-article:19405129pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19405129pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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