| pubmed-article:19399691 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19399691 | lifeskim:mentions | umls-concept:C1336596 | lld:lifeskim |
| pubmed-article:19399691 | lifeskim:mentions | umls-concept:C1167139 | lld:lifeskim |
| pubmed-article:19399691 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:19399691 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:19399691 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:19399691 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:19399691 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:19399691 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:19399691 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19399691 | pubmed:dateCreated | 2009-5-19 | lld:pubmed |
| pubmed-article:19399691 | pubmed:abstractText | The oncogene E2a-Pbx1 is formed by the t(1;19) translocation, which joins the N-terminal transactivation domain of E2a with the C-terminal homeodomain of PBX1. The goal of this work was to elucidate the mechanisms by which E2a-Pbx1 can lead to deregulated target gene expression. For reporter constructs it was shown that E2a-Pbx1 can activate transcription through homodimer elements (TGATTGAT) or through heterodimer elements with Hox proteins (e.g. TGATTAAT). We show a novel mechanism by which E2a-Pbx1 activates transcription of EF-9 using a promoter in intron 1 of the EF-9 gene, resulting in an aminoterminal truncated transcript. Our results indicate that the LDFS motif of E2a is essential for the transactivation of EF-9, but dispensable for transactivation of fibroblast growth factor 15. The E2a LDFS motif was also essential for proliferation of NIH3T3 fibroblasts but was dispensable for the E2a-Pbx1-induced differentiation arrest of myeloid progenitors. | lld:pubmed |
| pubmed-article:19399691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19399691 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19399691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19399691 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19399691 | pubmed:month | May | lld:pubmed |
| pubmed-article:19399691 | pubmed:issn | 1029-2403 | lld:pubmed |
| pubmed-article:19399691 | pubmed:author | pubmed-author:SykesDavid... | lld:pubmed |
| pubmed-article:19399691 | pubmed:author | pubmed-author:KampsMark PMP | lld:pubmed |
| pubmed-article:19399691 | pubmed:author | pubmed-author:SykesDavid... | lld:pubmed |
| pubmed-article:19399691 | pubmed:author | pubmed-author:ZemojtelTomas... | lld:pubmed |
| pubmed-article:19399691 | pubmed:author | pubmed-author:KolanczykMate... | lld:pubmed |
| pubmed-article:19399691 | pubmed:author | pubmed-author:DuchniewiczMa... | lld:pubmed |
| pubmed-article:19399691 | pubmed:author | pubmed-author:ScheeleJürgen... | lld:pubmed |
| pubmed-article:19399691 | pubmed:author | pubmed-author:DornAnnetteA | lld:pubmed |
| pubmed-article:19399691 | pubmed:author | pubmed-author:MöbestDietric... | lld:pubmed |
| pubmed-article:19399691 | pubmed:author | pubmed-author:RäppleDanielD | lld:pubmed |
| pubmed-article:19399691 | pubmed:author | pubmed-author:GantertMelani... | lld:pubmed |
| pubmed-article:19399691 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19399691 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:19399691 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19399691 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19399691 | pubmed:pagination | 816-28 | lld:pubmed |
| pubmed-article:19399691 | pubmed:dateRevised | 2009-11-9 | lld:pubmed |
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| pubmed-article:19399691 | pubmed:meshHeading | pubmed-meshheading:19399691... | lld:pubmed |
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| pubmed-article:19399691 | pubmed:meshHeading | pubmed-meshheading:19399691... | lld:pubmed |
| pubmed-article:19399691 | pubmed:meshHeading | pubmed-meshheading:19399691... | lld:pubmed |
| pubmed-article:19399691 | pubmed:meshHeading | pubmed-meshheading:19399691... | lld:pubmed |
| pubmed-article:19399691 | pubmed:meshHeading | pubmed-meshheading:19399691... | lld:pubmed |
| pubmed-article:19399691 | pubmed:meshHeading | pubmed-meshheading:19399691... | lld:pubmed |
| pubmed-article:19399691 | pubmed:meshHeading | pubmed-meshheading:19399691... | lld:pubmed |
| pubmed-article:19399691 | pubmed:meshHeading | pubmed-meshheading:19399691... | lld:pubmed |
| pubmed-article:19399691 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19399691 | pubmed:articleTitle | The Spt-Ada-Gcn5-acetyltransferase complex interaction motif of E2a is essential for a subset of transcriptional and oncogenic properties of E2a-Pbx1. | lld:pubmed |
| pubmed-article:19399691 | pubmed:affiliation | Department of Medicine I and Pharmacology I, University Hospital Freiburg, Freiburg, Germany. juergen.scheele@uniklinik-freiburg.de | lld:pubmed |
| pubmed-article:19399691 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19399691 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:21423 | entrezgene:pubmed | pubmed-article:19399691 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19399691 | lld:entrezgene |
