| pubmed-article:19387543 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19387543 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:19387543 | lifeskim:mentions | umls-concept:C0014239 | lld:lifeskim |
| pubmed-article:19387543 | lifeskim:mentions | umls-concept:C0740391 | lld:lifeskim |
| pubmed-article:19387543 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19387543 | pubmed:dateCreated | 2009-5-18 | lld:pubmed |
| pubmed-article:19387543 | pubmed:abstractText | Caspase-12 has been localized to endoplasmic reticulum (ER) and showed to involve ER stress-induced apoptosis. In the present work we investigated the temporospatial alterations of caspase-12 immunoreactivity in the penumbra following cerebral ischemia/reperfusion in rabbit. Transient cerebral ischemia was produced by intraluminal occlusion of the middle cerebral artery for 2 h followed by 1 h, 6 h, 1 day, 3 days, 7 days and 14 days of reperfusion. Caspase-12 immunohistochemistry was first increased in the penumbra 1 h after reperfusion, with a peak at day 1 to day 3, and then gradually decreased to basal level at day 14. The number of TUNEL-positive cells and ultrastructural observation of brain sections in the penumbra showed a similar change at the same time points. ER mediated by caspase-12 participated in apoptosis induced by cerebral ischemia/reperfusion injury, which may provide a new area for therapeutic intervention to ameliorate outcomes following cerebral ischemia. | lld:pubmed |
| pubmed-article:19387543 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19387543 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19387543 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19387543 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19387543 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19387543 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19387543 | pubmed:issn | 1590-3478 | lld:pubmed |
| pubmed-article:19387543 | pubmed:author | pubmed-author:YingLiL | lld:pubmed |
| pubmed-article:19387543 | pubmed:author | pubmed-author:LiChun-YanCY | lld:pubmed |
| pubmed-article:19387543 | pubmed:author | pubmed-author:YangJi-PingJP | lld:pubmed |
| pubmed-article:19387543 | pubmed:author | pubmed-author:LiuHuai-JunHJ | lld:pubmed |
| pubmed-article:19387543 | pubmed:author | pubmed-author:LiuRui-ChunRC | lld:pubmed |
| pubmed-article:19387543 | pubmed:author | pubmed-author:WangCang-HaiC... | lld:pubmed |
| pubmed-article:19387543 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19387543 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:19387543 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19387543 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19387543 | pubmed:pagination | 227-32 | lld:pubmed |
| pubmed-article:19387543 | pubmed:meshHeading | pubmed-meshheading:19387543... | lld:pubmed |
| pubmed-article:19387543 | pubmed:meshHeading | pubmed-meshheading:19387543... | lld:pubmed |
| pubmed-article:19387543 | pubmed:meshHeading | pubmed-meshheading:19387543... | lld:pubmed |
| pubmed-article:19387543 | pubmed:meshHeading | pubmed-meshheading:19387543... | lld:pubmed |
| pubmed-article:19387543 | pubmed:meshHeading | pubmed-meshheading:19387543... | lld:pubmed |
| pubmed-article:19387543 | pubmed:meshHeading | pubmed-meshheading:19387543... | lld:pubmed |
| pubmed-article:19387543 | pubmed:meshHeading | pubmed-meshheading:19387543... | lld:pubmed |
| pubmed-article:19387543 | pubmed:meshHeading | pubmed-meshheading:19387543... | lld:pubmed |
| pubmed-article:19387543 | pubmed:meshHeading | pubmed-meshheading:19387543... | lld:pubmed |
| pubmed-article:19387543 | pubmed:meshHeading | pubmed-meshheading:19387543... | lld:pubmed |
| pubmed-article:19387543 | pubmed:meshHeading | pubmed-meshheading:19387543... | lld:pubmed |
| pubmed-article:19387543 | pubmed:meshHeading | pubmed-meshheading:19387543... | lld:pubmed |
| pubmed-article:19387543 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19387543 | pubmed:articleTitle | Endoplasmic reticulum in the penumbra following middle cerebral artery occlusion in the rabbit. | lld:pubmed |
| pubmed-article:19387543 | pubmed:affiliation | Department of Medical Imaging, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, Hebei Province, China. huaijun_hb@yahoo.com.cn | lld:pubmed |
| pubmed-article:19387543 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19387543 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19387543 | lld:entrezgene |
