| pubmed-article:19381674 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19381674 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19381674 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19381674 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:19381674 | lifeskim:mentions | umls-concept:C0252527 | lld:lifeskim |
| pubmed-article:19381674 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:19381674 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:19381674 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19381674 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:19381674 | lifeskim:mentions | umls-concept:C1516044 | lld:lifeskim |
| pubmed-article:19381674 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:19381674 | lifeskim:mentions | umls-concept:C0449379 | lld:lifeskim |
| pubmed-article:19381674 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19381674 | pubmed:dateCreated | 2009-7-24 | lld:pubmed |
| pubmed-article:19381674 | pubmed:abstractText | Galectin-1 (gal-1) triggers T cell death by several distinct intracellular pathways including the activation of the death-receptor pathway. The aim of this study was to investigate whether gal-1 induced activation of the death-receptor pathway in Jurkat T lymphocytes mediates apoptosis via the mitochondrial pathway linked by truncated Bid (tBid). We demonstrate that gal-1 induced proteolytic cleavage of the death agonist Bid, a member of the Bcl-2/Bcl-xL family and a substrate of activated caspase-8, was inhibited by caspase-8 inhibitor II (Z-IETD-FMK). Downstream of Bid, gal-1 stimulated mitochondrial cytochrome c release as well as the activation and proteolytic processing of initiator procaspase-9 were effectively decreased by caspase-8 inhibitor II. Blocking of gal-1 induced cleavage of effector procaspase-3 by caspase-8 inhibitor II as well as by caspase-9 inhibitors I (Z-LEHD-FMK) and III (Ac-LEHD-CMK) indicates that receptor and mitochondrial pathways converged in procaspase-3 activation and contribute to proteolytic processing of effector procaspase-6 and -7. Western blot analyses and immunofluorescence staining revealed that exposure of Jurkat T cells to gal-1 resulted in the cleavage of the DNA-repair enzyme poly (ADP-ribose) polymerase, cytoskeletal alpha-fodrin, and nuclear lamin A as substrates of activated caspases. Our data demonstrate that Bid provides a connection between the death receptor and the mitochondrial pathway of gal-1 induced apoptosis in human Jurkat T lymphocytes. | lld:pubmed |
| pubmed-article:19381674 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19381674 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19381674 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19381674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19381674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19381674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19381674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19381674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19381674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19381674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19381674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19381674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19381674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19381674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19381674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19381674 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19381674 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19381674 | pubmed:issn | 1432-119X | lld:pubmed |
| pubmed-article:19381674 | pubmed:author | pubmed-author:JonasLudwigL | lld:pubmed |
| pubmed-article:19381674 | pubmed:author | pubmed-author:JeschkeUdoU | lld:pubmed |
| pubmed-article:19381674 | pubmed:author | pubmed-author:TiedgeMarkusM | lld:pubmed |
| pubmed-article:19381674 | pubmed:author | pubmed-author:WalzelHermann... | lld:pubmed |
| pubmed-article:19381674 | pubmed:author | pubmed-author:PöhlandRalfR | lld:pubmed |
| pubmed-article:19381674 | pubmed:author | pubmed-author:BrandtBettina... | lld:pubmed |
| pubmed-article:19381674 | pubmed:author | pubmed-author:LangeFalkoF | lld:pubmed |
| pubmed-article:19381674 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19381674 | pubmed:volume | 132 | lld:pubmed |
| pubmed-article:19381674 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19381674 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19381674 | pubmed:pagination | 211-23 | lld:pubmed |
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| pubmed-article:19381674 | pubmed:meshHeading | pubmed-meshheading:19381674... | lld:pubmed |
| pubmed-article:19381674 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19381674 | pubmed:articleTitle | Galectin-1 induced activation of the mitochondrial apoptotic pathway: evidence for a connection between death-receptor and mitochondrial pathways in human Jurkat T lymphocytes. | lld:pubmed |
| pubmed-article:19381674 | pubmed:affiliation | Medical Faculty, Institute of Medical Biochemistry and Molecular Biology, Schillingallee 70, Rostock, Germany. | lld:pubmed |
| pubmed-article:19381674 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19381674 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:637 | entrezgene:pubmed | pubmed-article:19381674 | lld:entrezgene |
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