| pubmed-article:19379665 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19379665 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:19379665 | lifeskim:mentions | umls-concept:C0011429 | lld:lifeskim |
| pubmed-article:19379665 | lifeskim:mentions | umls-concept:C0053574 | lld:lifeskim |
| pubmed-article:19379665 | lifeskim:mentions | umls-concept:C0057252 | lld:lifeskim |
| pubmed-article:19379665 | lifeskim:mentions | umls-concept:C1533591 | lld:lifeskim |
| pubmed-article:19379665 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:19379665 | lifeskim:mentions | umls-concept:C1554080 | lld:lifeskim |
| pubmed-article:19379665 | lifeskim:mentions | umls-concept:C1706198 | lld:lifeskim |
| pubmed-article:19379665 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:19379665 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19379665 | pubmed:dateCreated | 2009-5-15 | lld:pubmed |
| pubmed-article:19379665 | pubmed:abstractText | Targeted disruption of the dentin sialophosphoprotein (DSPP) gene in the mice (Dspp(-/-)) results in dentin mineralization defects with enlarged predentin phenotype similar to human dentinogenesis imperfecta type III. Using DSPP/biglycan (Dspp(-/-)Bgn(-/0)) and DSPP/decorin (Dspp(-/-)Dcn(-/-)) double knockout mice, here we determined that the enlarged predentin layer in Dspp(-/-) teeth is rescued in the absence of decorin, but not in the absence of biglycan. However, Fourier transform infrared (FTIR) spectroscopy analysis reveals similar hypomineralization of dentin in both Dspp(-/-)Bgn(-/0) and Dspp(-/-)Dcn(-/-) teeth. Atomic force microscopy (AFM) analysis of collagen fibrils in dentin shows subtle differences in the collagen fibril morphology in these genotypes. The reduction of enlarged predentin in Dspp(-/-)Dcn(-/-) mice suggests that the elevated level of decorin in Dspp(-/-) predentin interferes with the mineralization process at the dentin mineralization front. On the other hand, the lack of DSPP and biglycan leads to the increased number of calcospherites in Dspp(-/-)Bgn(-/0) predentin, suggesting that a failure in coalescence of calcospherites was augmented in Dspp(-/-)Bgn(-/0) teeth as compared to Dspp(-/-) teeth. These findings indicate that normal expression of small leucine rich proteoglycans, such as biglycan and decorin, plays an important role in the highly orchestrated process of dentin mineralization. | lld:pubmed |
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| pubmed-article:19379665 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19379665 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19379665 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19379665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19379665 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19379665 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19379665 | pubmed:issn | 1569-1802 | lld:pubmed |
| pubmed-article:19379665 | pubmed:author | pubmed-author:KulkarniAshok... | lld:pubmed |
| pubmed-article:19379665 | pubmed:author | pubmed-author:WangYongY | lld:pubmed |
| pubmed-article:19379665 | pubmed:author | pubmed-author:YoungMarian... | lld:pubmed |
| pubmed-article:19379665 | pubmed:author | pubmed-author:WangZhigangZ | lld:pubmed |
| pubmed-article:19379665 | pubmed:author | pubmed-author:IozzoRenato... | lld:pubmed |
| pubmed-article:19379665 | pubmed:author | pubmed-author:HaruyamaNaoto... | lld:pubmed |
| pubmed-article:19379665 | pubmed:author | pubmed-author:YaoXiaomeiX | lld:pubmed |
| pubmed-article:19379665 | pubmed:author | pubmed-author:SreenathTadur... | lld:pubmed |
| pubmed-article:19379665 | pubmed:author | pubmed-author:SuzukiShigeki... | lld:pubmed |
| pubmed-article:19379665 | pubmed:author | pubmed-author:HoneycuttCher... | lld:pubmed |
| pubmed-article:19379665 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19379665 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:19379665 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19379665 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19379665 | pubmed:pagination | 129-36 | lld:pubmed |
| pubmed-article:19379665 | pubmed:dateRevised | 2011-3-8 | lld:pubmed |
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