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pubmed-article:1937611pubmed:abstractTextImmune status of 22 patients of ataxia telangiectasia was studied over a period of 8 yr (mean age of patients: 9.5 +/- 3 yr; 9 of 22 were siblings). Low T-cell number was observed in 14 of 19 patients but the response to PHA challenge done in 10 patients was normal and migration inhibition to BCG antigen was positive in 6 of 6 patients. IgM defect was seen in 2 out of 18 patients and serum IgA was deficient in 10 out of 18 patients. Salivary IgA was also absent in these children. Four children had high spontaneous NBT reduction. None of the patients had lymphoma, leukemia or any other malignancy at the time of presentation. Candida killing was normal in all patients. The presenting feature related to the CNS in almost all children and gross infections were not seen.lld:pubmed
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pubmed-article:1937611pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:1937611pubmed:articleTitleImmune status in ataxia telangiectasia.lld:pubmed
pubmed-article:1937611pubmed:affiliationDepartment of Immunopathology, Postgraduate Institute of Medical Education & Research, Chandigarh.lld:pubmed
pubmed-article:1937611pubmed:publicationTypeJournal Articlelld:pubmed