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pubmed-article:19374805pubmed:abstractTextThymidylate synthase (TS) catalyses the conversion of deoxy-uridylate to deoxy-thymidylate and is a key enzyme for DNA synthesis. TS is the target enzyme of 5-fluorouracil (5-FU) and involved in folate metabolism. TS gene polymorphisms play an important role in the efficiency of fluorouracil activity in vivo. This study investigated the allelic frequencies and distribution characters of single-nucleotide polymorphisms within the coding region (cSNPs) of TS gene in Chinese children with acute leukemia (AL) and normal control children in order to explore the possible relationship between the cSNP in human TS gene and chemotherapeutic effects of 5-fluorouracils.lld:pubmed
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pubmed-article:19374805pubmed:authorpubmed-author:ZhangMinMlld:pubmed
pubmed-article:19374805pubmed:authorpubmed-author:ChenXiao-WenX...lld:pubmed
pubmed-article:19374805pubmed:authorpubmed-author:LiCheng-RongC...lld:pubmed
pubmed-article:19374805pubmed:authorpubmed-author:LiChang-GangC...lld:pubmed
pubmed-article:19374805pubmed:authorpubmed-author:ShiHong-SongH...lld:pubmed
pubmed-article:19374805pubmed:authorpubmed-author:YueLi-JieLJlld:pubmed
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pubmed-article:19374805pubmed:volume11lld:pubmed
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pubmed-article:19374805pubmed:year2009lld:pubmed
pubmed-article:19374805pubmed:articleTitle[Polymorphisms of thymidylate synthase gene detected by RT-PCR-denaturing gradient gel electrophoresis in children with acute leukemia].lld:pubmed
pubmed-article:19374805pubmed:affiliationShenzhen Institute of Pediatrics, Shenzhen Children's Hospital, Shenzhen, Guangdong 518026, China.lld:pubmed
pubmed-article:19374805pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19374805pubmed:publicationTypeEnglish Abstractlld:pubmed
pubmed-article:19374805pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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