| pubmed-article:19372304 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19372304 | lifeskim:mentions | umls-concept:C0039005 | lld:lifeskim |
| pubmed-article:19372304 | lifeskim:mentions | umls-concept:C1522564 | lld:lifeskim |
| pubmed-article:19372304 | lifeskim:mentions | umls-concept:C0035126 | lld:lifeskim |
| pubmed-article:19372304 | lifeskim:mentions | umls-concept:C1708096 | lld:lifeskim |
| pubmed-article:19372304 | lifeskim:mentions | umls-concept:C0040018 | lld:lifeskim |
| pubmed-article:19372304 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19372304 | lifeskim:mentions | umls-concept:C2352099 | lld:lifeskim |
| pubmed-article:19372304 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19372304 | pubmed:dateCreated | 2009-5-27 | lld:pubmed |
| pubmed-article:19372304 | pubmed:abstractText | Myocardial ischemia-reperfusion (IR) injury occurs frequently in the setting of hypercholesterolemia. We investigated the potential efficacy of a novel thrombin fragment (TP508) on IR injury in a hypercholesterolemic porcine model. Twenty-one hypercholesterolemic male Yucatan pigs underwent 60 min of mid-left anterior descending coronary artery occlusion followed by 120 min of reperfusion. Pigs received either placebo (control, n = 7) or TP508 in two doses (TP508 low dose, n = 7, as bolus of 0.5 mg/kg 50 min into ischemia and an infusion of 1.25 mg.kg(-1).h(-1) during reperfusion period or TP508 high dose, n = 7, a double dose of TP508 low-dose group). Myocardial function was monitored throughout the experiment. The area at risk and myocardial necrosis were determined by Monastryl blue/triphenyl tetrazolium chloride staining. Apoptosis in the ischemic territory was assessed. Coronary microvascular reactivity to endothelium-dependent and -independent factors was measured. Myocardial necrosis was lower in both TP508-treated groups vs. control (P < 0.05). Regional left ventricular function was improved only in the TP508 high-dose group (P < 0.05). Endothelium-dependent coronary microvascular reactivity was greater in both TP508-treated groups (P < 0.05) vs. control. The expression of proteins favoring cell survival, 90-kDa heat shock protein and phospho-Bad (Ser112) was higher in the TP508 high-dose group (P < 0.05). The expression of the cell death signaling proteins, cleaved caspase-3 (P < 0.05), apoptosis-inducing factor (P < 0.05), and poly-ADP ribose polymerase (P = 0.07) was lower in the TP508 low-dose group vs. TP508 high-dose and control. The terminal deoxynucleotidyl transferase dUTP-mediated nick-end labeling positive cell count was lower in both TP508 groups compared with the control (P < 0.05). This study demonstrates that, in hypercholesterolemic pigs, TP508 decreases myocardial necrosis and apoptosis after IR. Thus TP508 may offer a novel approach in protecting the myocardium from IR injury. | lld:pubmed |
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| pubmed-article:19372304 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19372304 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19372304 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19372304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19372304 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19372304 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19372304 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:19372304 | pubmed:author | pubmed-author:ClementsRicha... | lld:pubmed |
| pubmed-article:19372304 | pubmed:author | pubmed-author:BianchiCesari... | lld:pubmed |
| pubmed-article:19372304 | pubmed:author | pubmed-author:SellkeFrank... | lld:pubmed |
| pubmed-article:19372304 | pubmed:author | pubmed-author:WagstaffJohnJ | lld:pubmed |
| pubmed-article:19372304 | pubmed:author | pubmed-author:FengJunJ | lld:pubmed |
| pubmed-article:19372304 | pubmed:author | pubmed-author:LiuYuhongY | lld:pubmed |
| pubmed-article:19372304 | pubmed:author | pubmed-author:OsipovRobert... | lld:pubmed |
| pubmed-article:19372304 | pubmed:author | pubmed-author:RobichMichael... | lld:pubmed |
| pubmed-article:19372304 | pubmed:author | pubmed-author:GlazerHilary... | lld:pubmed |
| pubmed-article:19372304 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19372304 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19372304 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19372304 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19372304 | pubmed:pagination | 1993-2001 | lld:pubmed |
| pubmed-article:19372304 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
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