| pubmed-article:19368886 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19368886 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19368886 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:19368886 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:19368886 | lifeskim:mentions | umls-concept:C0961834 | lld:lifeskim |
| pubmed-article:19368886 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19368886 | pubmed:dateCreated | 2009-4-16 | lld:pubmed |
| pubmed-article:19368886 | pubmed:abstractText | Abasic sites are among the most abundant DNA lesions formed in human cells, and they present a strong block to replication. DNA polymerase iota (Poliota) is one of the few DNA Pols that does not follow the A-rule opposite an abasic site. We present here three structures of human Poliota in complex with DNAs containing an abasic lesion and dGTP, dTTP, or dATP as the incoming nucleotide. The structures reveal a mechanism of translesion synthesis across an abasic lesion that differs from that in other Pols. Both the abasic lesion and the incoming dNTPs are intrahelical and are closely apposed across a constricted active site cleft. The dNTPs partake in distinct networks of hydrogen bonds in the "void" opposite the lesion. These different patterns of hydrogen bonds, as well as stacking interactions, may underlie Poliota's small preference for insertion of dGTP over other nucleotides opposite this common lesion. | lld:pubmed |
| pubmed-article:19368886 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19368886 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19368886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368886 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19368886 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19368886 | pubmed:issn | 0969-2126 | lld:pubmed |
| pubmed-article:19368886 | pubmed:author | pubmed-author:FellnerJJ | lld:pubmed |
| pubmed-article:19368886 | pubmed:author | pubmed-author:JohnsonRobert... | lld:pubmed |
| pubmed-article:19368886 | pubmed:author | pubmed-author:PrakashLouise... | lld:pubmed |
| pubmed-article:19368886 | pubmed:author | pubmed-author:PrakashSatyaS | lld:pubmed |
| pubmed-article:19368886 | pubmed:author | pubmed-author:AggarwalAneel... | lld:pubmed |
| pubmed-article:19368886 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19368886 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19368886 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:19368886 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19368886 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19368886 | pubmed:pagination | 530-7 | lld:pubmed |
| pubmed-article:19368886 | pubmed:dateRevised | 2010-12-17 | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:meshHeading | pubmed-meshheading:19368886... | lld:pubmed |
| pubmed-article:19368886 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19368886 | pubmed:articleTitle | DNA synthesis across an abasic lesion by human DNA polymerase iota. | lld:pubmed |
| pubmed-article:19368886 | pubmed:affiliation | Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY 10029, USA. | lld:pubmed |
| pubmed-article:19368886 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19368886 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:11201 | entrezgene:pubmed | pubmed-article:19368886 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19368886 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19368886 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19368886 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19368886 | lld:pubmed |
