| pubmed-article:19368858 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19368858 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:19368858 | lifeskim:mentions | umls-concept:C0011570 | lld:lifeskim |
| pubmed-article:19368858 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19368858 | pubmed:dateCreated | 2009-4-16 | lld:pubmed |
| pubmed-article:19368858 | pubmed:abstractText | Several studies have reported an association between the ApolipoproteinE-epsilon4 (APOE4) allele and depression among elders. However others have failed to find an association. Since APOE4 is a well recognized risk factor for Alzheimer dementia, cognitive status may represent an important confounder between APOE4 and depression. In this investigation, we examined the relationship between the ApolipoproteinE-epsilon4 allele and depression among elders accounting for cognitive status. Using a case-control design (n=1052), we investigated the association between ApolipoproteinE-epsilon4 and depression in Alzheimer disease patients (n=528) and in cognitively intact controls (n=524). We demonstrated an apparent association between the APOE4 allele and depression in the combined dataset (p=0.001) when not controlling for cognitive status. However, once stratified by the presence of Alzheimer disease, there was no association in either the Alzheimer group (p=0.290) or the cognitively intact controls (p=0.494). In this dataset there is no association between the ApolipoproteinE-epsilon4 allele and depression among those with Alzheimer disease or among cognitively intact elders. However there is a significant association between female gender and depression in the cognitively intact (p=0.003) but not among those with Alzheimer disease. Additionally, individuals with Alzheimer disease and depression had a significantly younger age of onset for their Alzheimer disease than those without depression (p=0.017). | lld:pubmed |
| pubmed-article:19368858 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368858 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368858 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368858 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368858 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368858 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368858 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368858 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368858 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368858 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368858 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19368858 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368858 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19368858 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19368858 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19368858 | pubmed:month | May | lld:pubmed |
| pubmed-article:19368858 | pubmed:issn | 1872-7972 | lld:pubmed |
| pubmed-article:19368858 | pubmed:author | pubmed-author:GilbertJohn... | lld:pubmed |
| pubmed-article:19368858 | pubmed:author | pubmed-author:Pericak-Vance... | lld:pubmed |
| pubmed-article:19368858 | pubmed:author | pubmed-author:HainesJonatha... | lld:pubmed |
| pubmed-article:19368858 | pubmed:author | pubmed-author:MartinEden... | lld:pubmed |
| pubmed-article:19368858 | pubmed:author | pubmed-author:SliferMichael... | lld:pubmed |
| pubmed-article:19368858 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19368858 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19368858 | pubmed:volume | 455 | lld:pubmed |
| pubmed-article:19368858 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19368858 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19368858 | pubmed:pagination | 116-9 | lld:pubmed |
| pubmed-article:19368858 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:19368858 | pubmed:meshHeading | pubmed-meshheading:19368858... | lld:pubmed |
| pubmed-article:19368858 | pubmed:meshHeading | pubmed-meshheading:19368858... | lld:pubmed |
| pubmed-article:19368858 | pubmed:meshHeading | pubmed-meshheading:19368858... | lld:pubmed |
| pubmed-article:19368858 | pubmed:meshHeading | pubmed-meshheading:19368858... | lld:pubmed |
| pubmed-article:19368858 | pubmed:meshHeading | pubmed-meshheading:19368858... | lld:pubmed |
| pubmed-article:19368858 | pubmed:meshHeading | pubmed-meshheading:19368858... | lld:pubmed |
| pubmed-article:19368858 | pubmed:meshHeading | pubmed-meshheading:19368858... | lld:pubmed |
| pubmed-article:19368858 | pubmed:meshHeading | pubmed-meshheading:19368858... | lld:pubmed |
| pubmed-article:19368858 | pubmed:meshHeading | pubmed-meshheading:19368858... | lld:pubmed |
| pubmed-article:19368858 | pubmed:meshHeading | pubmed-meshheading:19368858... | lld:pubmed |
| pubmed-article:19368858 | pubmed:meshHeading | pubmed-meshheading:19368858... | lld:pubmed |
| pubmed-article:19368858 | pubmed:meshHeading | pubmed-meshheading:19368858... | lld:pubmed |
| pubmed-article:19368858 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19368858 | pubmed:articleTitle | Resolving the relationship between ApolipoproteinE and depression. | lld:pubmed |
| pubmed-article:19368858 | pubmed:affiliation | Miami Institute for Human Genomics, University of Miami, Miami, FL 33136, USA. mslifer@med.miami.edu | lld:pubmed |
| pubmed-article:19368858 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19368858 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19368858 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:348 | entrezgene:pubmed | pubmed-article:19368858 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19368858 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19368858 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19368858 | lld:pubmed |
