Linked Life Data

1936590

Source:http://linkedlifedata.com/resource/pubmed/id/1936590

Statements in which the resource exists.
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pubmed-article:1936590pubmed:abstractTextPhorbol esters translocatively activate and subsequently downregulate protein kinase C and insulin-stimulated glucose uptake in rat adipocytes. This study examined the possibility that other translocative activators of protein kinase C in rat adipocytes, e.g., insulin and glucose, provoke similar downregulating effects. Pretreatment of rat adipocytes for 20-24 h with phorbol esters, 3 nM insulin, 20 mM glucose, or 3 nM insulin plus 20 mM glucose resulted in concomitant decreases in protein kinase C and insulin-stimulated (or phorbol ester-stimulated) [3H]-2-deoxyglucose uptake. Downregulating effects of glucose on protein kinase C and insulin-stimulated [3H]-2-deoxyglucose uptake were also evident within 30 min in adipocytes freshly incubated in medium containing 5-20 mM, rather than 0, glucose. These findings confirm that protein kinase C is required during insulin-stimulated glucose uptake and raise the possibility that downregulation of protein kinase C by continued translocative activation of the enzyme may contribute (along with other factors) to impaired responsiveness of the glucose transport system after prolonged insulin and/or glucose treatment.lld:pubmed
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pubmed-article:1936590pubmed:pagination1274-81lld:pubmed
pubmed-article:1936590pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:1936590pubmed:articleTitleDownregulation of protein kinase C and insulin-stimulated 2-deoxyglucose uptake in rat adipocytes by phorbol esters, glucose, and insulin.lld:pubmed
pubmed-article:1936590pubmed:affiliationJ.A. Haley Veterans Hospital, Tampa, FL 33612.lld:pubmed
pubmed-article:1936590pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:1936590pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:1936590pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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