| pubmed-article:19365153 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19365153 | lifeskim:mentions | umls-concept:C0599779 | lld:lifeskim |
| pubmed-article:19365153 | lifeskim:mentions | umls-concept:C0022890 | lld:lifeskim |
| pubmed-article:19365153 | lifeskim:mentions | umls-concept:C0001563 | lld:lifeskim |
| pubmed-article:19365153 | lifeskim:mentions | umls-concept:C0443146 | lld:lifeskim |
| pubmed-article:19365153 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:19365153 | lifeskim:mentions | umls-concept:C0005290 | lld:lifeskim |
| pubmed-article:19365153 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19365153 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19365153 | pubmed:dateCreated | 2009-7-17 | lld:pubmed |
| pubmed-article:19365153 | pubmed:abstractText | Induction of peripheral tolerance by oral administration of low-dose beta-tubulin antigen may be an effective, antigen-specific method to suppress experimental autoimmune hearing loss. Five groups of mice were fed with phosphate-buffered saline (PBS), ovalbumin (OVA), 20, 30 or 200 microg of beta-tubulin, respectively. All mice were then immunized by beta-tubulin. Hearing thresholds were measured before and after immunization. Inner ear histology and cytokine profile were examined. Mice fed with 20 or 30 microg of beta-tubulin showed less hearing loss and less inner ear damage compared to the groups treated with PBS, OVA or 200 microg of beta-tubulin. Interferon-gamma (IFN-gamma) was decreased while interleukin-4 (IL-4), IL-5, IL-13 and TGF-beta were increased in both sera and in cell culture supernatants of the mice fed with 20 or 30 microg of beta-tubulin. However, no cytokine profile change was found in the group treated with 200 microg of tubulin. These results suggest that a low dose of beta-tubulin is active orally in an antigen-specific fashion and capable of inhibiting the autoimmune reactions in the inner ear by suppressing Th1 (IFN-gamma) and increasing Th2 and Th3 (IL-4, IL-5, IL-13 and TGF-beta) cytokines. Oral antigen tolerance may be used to treat autoimmune inner ear disease. | lld:pubmed |
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| pubmed-article:19365153 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19365153 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19365153 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19365153 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19365153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19365153 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19365153 | pubmed:issn | 1423-0275 | lld:pubmed |
| pubmed-article:19365153 | pubmed:author | pubmed-author:ZhouBinB | lld:pubmed |
| pubmed-article:19365153 | pubmed:author | pubmed-author:CaiQingQ | lld:pubmed |
| pubmed-article:19365153 | pubmed:author | pubmed-author:DuXiaopingX | lld:pubmed |
| pubmed-article:19365153 | pubmed:author | pubmed-author:YooTaijuneT | lld:pubmed |
| pubmed-article:19365153 | pubmed:author | pubmed-author:CaiChunC | lld:pubmed |
| pubmed-article:19365153 | pubmed:author | pubmed-author:KermanyMohamm... | lld:pubmed |
| pubmed-article:19365153 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19365153 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:19365153 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19365153 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19365153 | pubmed:pagination | 135-41 | lld:pubmed |
| pubmed-article:19365153 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
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| pubmed-article:19365153 | pubmed:meshHeading | pubmed-meshheading:19365153... | lld:pubmed |
| pubmed-article:19365153 | pubmed:meshHeading | pubmed-meshheading:19365153... | lld:pubmed |
| pubmed-article:19365153 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19365153 | pubmed:articleTitle | Induction of tolerance by oral administration of beta-tubulin in an animal model of autoimmune inner ear disease. | lld:pubmed |
| pubmed-article:19365153 | pubmed:affiliation | Department of Medicine, Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA. | lld:pubmed |
| pubmed-article:19365153 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19365153 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
