| pubmed-article:19365110 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19365110 | lifeskim:mentions | umls-concept:C0033147 | lld:lifeskim |
| pubmed-article:19365110 | lifeskim:mentions | umls-concept:C0023685 | lld:lifeskim |
| pubmed-article:19365110 | lifeskim:mentions | umls-concept:C0024090 | lld:lifeskim |
| pubmed-article:19365110 | lifeskim:mentions | umls-concept:C0521329 | lld:lifeskim |
| pubmed-article:19365110 | lifeskim:mentions | umls-concept:C0003893 | lld:lifeskim |
| pubmed-article:19365110 | lifeskim:mentions | umls-concept:C0034963 | lld:lifeskim |
| pubmed-article:19365110 | lifeskim:mentions | umls-concept:C0439810 | lld:lifeskim |
| pubmed-article:19365110 | lifeskim:mentions | umls-concept:C0993608 | lld:lifeskim |
| pubmed-article:19365110 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19365110 | pubmed:dateCreated | 2009-11-20 | lld:pubmed |
| pubmed-article:19365110 | pubmed:abstractText | Total disk arthroplasty (TDA) is a new procedure that replaces the intervertebral disk space with an artificial motion segment and necessitates the resection of the anterior longitudinal ligament (ALL). We assessed whether a collagen-based graft made from porcine small-intestine submucosa (SIS) can be used as a regenerative scaffold to restore the function and structure of the ALL in the lumbar spine. A total of 10 mature male baboons underwent TDA at L5-L6 using one of two treatments: (1) TDA only (n = 5) or (2) TDA combined with SIS (n = 5). Six months postoperatively, mock revision surgery was performed to assess tissue adhesions followed by non-destructive multidirectional flexibility testing of the spinal segment. The vertebral segments were then processed for histology. The tissue adhesion score was 2.8 +/- 0.8 in the TDA only group and 1.8 +/- 1.4 in the TDA-SIS group (p = 0.2). Segmental range of motion and the length of the neutral zone were similar in both groups. Histology showed that the SIS scaffold led to an organized ligamentous structure with a significantly (p = 0.027) higher thickness (2.18 +/- 0.25 mm) compared to the connective tissue structure in the TDA-only group (1.66 +/- 0.33 mm). We concluded that using a SIS bioscaffold after TDA did not lead to increased great vessel adhesion while its use facilitated the formation of highly organized ligamentous tissues. However, the SIS- induced and newly formed ligamentous tissue anterior to the spinal segment did not lead to a measurable limitation of spinal extension. | lld:pubmed |
| pubmed-article:19365110 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19365110 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19365110 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19365110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19365110 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19365110 | pubmed:issn | 1422-6421 | lld:pubmed |
| pubmed-article:19365110 | pubmed:author | pubmed-author:McAfeePaul... | lld:pubmed |
| pubmed-article:19365110 | pubmed:author | pubmed-author:CunninghamBry... | lld:pubmed |
| pubmed-article:19365110 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:19365110 | pubmed:author | pubmed-author:BervenSigurd... | lld:pubmed |
| pubmed-article:19365110 | pubmed:author | pubmed-author:HuNianbinN | lld:pubmed |
| pubmed-article:19365110 | pubmed:author | pubmed-author:BeatsonHelen... | lld:pubmed |
| pubmed-article:19365110 | pubmed:copyrightInfo | 2009 S. Karger AG, Basel. | lld:pubmed |
| pubmed-article:19365110 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19365110 | pubmed:volume | 190 | lld:pubmed |
| pubmed-article:19365110 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19365110 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19365110 | pubmed:pagination | 347-55 | lld:pubmed |
| pubmed-article:19365110 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:meshHeading | pubmed-meshheading:19365110... | lld:pubmed |
| pubmed-article:19365110 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19365110 | pubmed:articleTitle | Regeneration of a spinal ligament after total lumbar disk arthroplasty in primates. | lld:pubmed |
| pubmed-article:19365110 | pubmed:affiliation | Department of Orthopedic Surgery, Union Memorial Hospital, Baltimore, MD, USA. | lld:pubmed |
| pubmed-article:19365110 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19365110 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
