pubmed-article:19362833 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:19362833 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:19362833 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
pubmed-article:19362833 | lifeskim:mentions | umls-concept:C0268563 | lld:lifeskim |
pubmed-article:19362833 | lifeskim:mentions | umls-concept:C1511681 | lld:lifeskim |
pubmed-article:19362833 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
pubmed-article:19362833 | pubmed:issue | 10 | lld:pubmed |
pubmed-article:19362833 | pubmed:dateCreated | 2009-5-4 | lld:pubmed |
pubmed-article:19362833 | pubmed:abstractText | The inhibitory activity of base-modified SAH analogues and the specificity of inhibiting human DNMT1 and DNMT3b2 enzymes was explored. The 6-amino group was essential while the 7-N of the adenine ring of SAH could be replaced by CH- without loss of activity against both enzymes. The introduction of small groups at the 2-position of the adenine moiety favors DNMT1 over DNMT3b2 inhibition whereas alkylation of the N(6)-amino moiety favors the inhibition of DNMT3b2 enzyme. | lld:pubmed |
pubmed-article:19362833 | pubmed:language | eng | lld:pubmed |
pubmed-article:19362833 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19362833 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:19362833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19362833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19362833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19362833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19362833 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:19362833 | pubmed:month | May | lld:pubmed |
pubmed-article:19362833 | pubmed:issn | 1464-3405 | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:DelormeDaniel... | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:MacLeodA... | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:BestermanJeff... | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:ClaridgeSteph... | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:VaisburgArkad... | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:BernsteinNaom... | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:ZhanLijieL | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:SaavedraOscar... | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:RaeppelFranck... | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:RahilJubrailJ | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:WahhabAmalA | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:PetschnerAndr... | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:IsakovicLjubo... | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:LlewellynDavi... | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:EloweNadineN | lld:pubmed |
pubmed-article:19362833 | pubmed:author | pubmed-author:BeaulieuNorma... | lld:pubmed |
pubmed-article:19362833 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:19362833 | pubmed:day | 15 | lld:pubmed |
pubmed-article:19362833 | pubmed:volume | 19 | lld:pubmed |
pubmed-article:19362833 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:19362833 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:19362833 | pubmed:pagination | 2747-51 | lld:pubmed |
pubmed-article:19362833 | pubmed:meshHeading | pubmed-meshheading:19362833... | lld:pubmed |
pubmed-article:19362833 | pubmed:meshHeading | pubmed-meshheading:19362833... | lld:pubmed |
pubmed-article:19362833 | pubmed:meshHeading | pubmed-meshheading:19362833... | lld:pubmed |
pubmed-article:19362833 | pubmed:meshHeading | pubmed-meshheading:19362833... | lld:pubmed |
pubmed-article:19362833 | pubmed:meshHeading | pubmed-meshheading:19362833... | lld:pubmed |
pubmed-article:19362833 | pubmed:year | 2009 | lld:pubmed |
pubmed-article:19362833 | pubmed:articleTitle | SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. | lld:pubmed |
pubmed-article:19362833 | pubmed:affiliation | MethylGene Inc., Departments of Medicinal Chemistry, Montreal, Quebec, Canada. | lld:pubmed |
pubmed-article:19362833 | pubmed:publicationType | Journal Article | lld:pubmed |
http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19362833 | lld:chembl |