| pubmed-article:19359041 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19359041 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19359041 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:19359041 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:19359041 | lifeskim:mentions | umls-concept:C1520150 | lld:lifeskim |
| pubmed-article:19359041 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:19359041 | lifeskim:mentions | umls-concept:C0056184 | lld:lifeskim |
| pubmed-article:19359041 | lifeskim:mentions | umls-concept:C1155229 | lld:lifeskim |
| pubmed-article:19359041 | lifeskim:mentions | umls-concept:C1516356 | lld:lifeskim |
| pubmed-article:19359041 | lifeskim:mentions | umls-concept:C2348205 | lld:lifeskim |
| pubmed-article:19359041 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:19359041 | pubmed:dateCreated | 2009-5-20 | lld:pubmed |
| pubmed-article:19359041 | pubmed:abstractText | Mice prematurely expressing human CR2 (hCR2) in the B cell lineage have a defective B cell ontogeny and humoral immune response. We have previously determined altered tyrosine phosphorylation patterns within hCR2 transgenic mice, suggesting that irreversible changes in B cell signaling pathways had occurred, which could explain the B cell unresponsiveness associated with hCR2 transgene expression. In support of that assertion, we found that increasing antigen dose or addition of adjuvant had a minimal impact on the ability of B cells to respond to antigen. However, analysis of aged hCR2(high) mice (1 year plus) revealed that both B cell numbers, B cell sub-population distribution including expansion of a newly described B regulatory cell subset, and immune responses were comparable with age-matched hCR2 negative mice. Finally, we established that B cell unresponsiveness to antigen in aging wild type mice (1 year plus) was equivalent to that noted in 3-month-old hCR2(high) mice. This data provides evidence that 3-month-old hCR2(high) mice have a humoral immune system resembling aged mice and suggests that further examination of the precise molecular and cellular parallels between aged wild type mice and 3-month-old hCR2(high) mice could provide an important insight into the mechanisms which lead to B cell unresponsiveness in the aging immune system. | lld:pubmed |
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| pubmed-article:19359041 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19359041 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19359041 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19359041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19359041 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19359041 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19359041 | pubmed:issn | 1872-9142 | lld:pubmed |
| pubmed-article:19359041 | pubmed:author | pubmed-author:HolersV... | lld:pubmed |
| pubmed-article:19359041 | pubmed:author | pubmed-author:WangEddie C... | lld:pubmed |
| pubmed-article:19359041 | pubmed:author | pubmed-author:KulikLiudmila... | lld:pubmed |
| pubmed-article:19359041 | pubmed:author | pubmed-author:MarchbankKevi... | lld:pubmed |
