| pubmed-article:19357261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19357261 | lifeskim:mentions | umls-concept:C0072899 | lld:lifeskim |
| pubmed-article:19357261 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:19357261 | lifeskim:mentions | umls-concept:C1333225 | lld:lifeskim |
| pubmed-article:19357261 | lifeskim:mentions | umls-concept:C0220839 | lld:lifeskim |
| pubmed-article:19357261 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19357261 | lifeskim:mentions | umls-concept:C0444454 | lld:lifeskim |
| pubmed-article:19357261 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:19357261 | pubmed:dateCreated | 2009-4-9 | lld:pubmed |
| pubmed-article:19357261 | pubmed:abstractText | The synaptic insertion of GluR1-containing AMPA-type glutamate receptors (AMPARs) is critical for synaptic plasticity. However, mechanisms responsible for GluR1 insertion and retention at the synapse are unclear. The synapse-associated protein SAP97 directly binds GluR1 and participates in its forward trafficking from the Golgi network to the plasma membrane. Whether SAP97 also plays a role in scaffolding GluR1 at the postsynaptic membrane is controversial, attributable to its expression as a collection of alternatively spliced isoforms with ill-defined spatial and temporal distributions. In the present study, we have used live imaging and electrophysiology to demonstrate that two postsynaptic, N-terminal isoforms of SAP97 directly modulate the levels, dynamics, and function of synaptic GluR1-containing AMPARs. Specifically, the unique N-terminal domains confer distinct subsynaptic localizations onto SAP97, targeting the palmitoylated alpha-isoform to the postsynaptic density (PSD) and the L27 domain-containing beta-isoform primarily to non-PSD, perisynaptic regions. Consequently, alpha- and betaSAP97 differentially influence the subsynaptic localization and dynamics of AMPARs by creating binding sites for GluR1-containing receptors within their respective subdomains. These results indicate that N-terminal splicing of SAP97 can control synaptic strength by regulating the distribution of AMPARs and, hence, their responsiveness to presynaptically released glutamate. | lld:pubmed |
| pubmed-article:19357261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19357261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19357261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19357261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19357261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19357261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19357261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19357261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19357261 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19357261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19357261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19357261 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19357261 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:19357261 | pubmed:author | pubmed-author:GarnerCraig... | lld:pubmed |
| pubmed-article:19357261 | pubmed:author | pubmed-author:MontgomeryJoh... | lld:pubmed |
| pubmed-article:19357261 | pubmed:author | pubmed-author:DongLiL | lld:pubmed |
| pubmed-article:19357261 | pubmed:author | pubmed-author:SpechtChristi... | lld:pubmed |
| pubmed-article:19357261 | pubmed:author | pubmed-author:GenouxDavidD | lld:pubmed |
| pubmed-article:19357261 | pubmed:author | pubmed-author:GreenWilliam... | lld:pubmed |
| pubmed-article:19357261 | pubmed:author | pubmed-author:Leal-OrtizSer... | lld:pubmed |
| pubmed-article:19357261 | pubmed:author | pubmed-author:DrisdelRenald... | lld:pubmed |
| pubmed-article:19357261 | pubmed:author | pubmed-author:WaitesClariss... | lld:pubmed |
| pubmed-article:19357261 | pubmed:author | pubmed-author:HärtelKaiK | lld:pubmed |
| pubmed-article:19357261 | pubmed:author | pubmed-author:CheyneJuliett... | lld:pubmed |
| pubmed-article:19357261 | pubmed:author | pubmed-author:JeyifousOkunO | lld:pubmed |
| pubmed-article:19357261 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19357261 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:19357261 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:19357261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19357261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19357261 | pubmed:pagination | 4332-45 | lld:pubmed |
| pubmed-article:19357261 | pubmed:dateRevised | 2011-10-19 | lld:pubmed |
| pubmed-article:19357261 | pubmed:meshHeading | pubmed-meshheading:19357261... | lld:pubmed |
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| pubmed-article:19357261 | pubmed:meshHeading | pubmed-meshheading:19357261... | lld:pubmed |
| pubmed-article:19357261 | pubmed:meshHeading | pubmed-meshheading:19357261... | lld:pubmed |
| pubmed-article:19357261 | pubmed:meshHeading | pubmed-meshheading:19357261... | lld:pubmed |
| pubmed-article:19357261 | pubmed:meshHeading | pubmed-meshheading:19357261... | lld:pubmed |
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| pubmed-article:19357261 | pubmed:meshHeading | pubmed-meshheading:19357261... | lld:pubmed |
| pubmed-article:19357261 | pubmed:meshHeading | pubmed-meshheading:19357261... | lld:pubmed |
| pubmed-article:19357261 | pubmed:meshHeading | pubmed-meshheading:19357261... | lld:pubmed |
| pubmed-article:19357261 | pubmed:meshHeading | pubmed-meshheading:19357261... | lld:pubmed |
| pubmed-article:19357261 | pubmed:meshHeading | pubmed-meshheading:19357261... | lld:pubmed |
| pubmed-article:19357261 | pubmed:meshHeading | pubmed-meshheading:19357261... | lld:pubmed |
| pubmed-article:19357261 | pubmed:meshHeading | pubmed-meshheading:19357261... | lld:pubmed |
| pubmed-article:19357261 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19357261 | pubmed:articleTitle | Synaptic SAP97 isoforms regulate AMPA receptor dynamics and access to presynaptic glutamate. | lld:pubmed |
| pubmed-article:19357261 | pubmed:affiliation | Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, 1201 Welch Road, Palo Alto, CA 94304-5485, USA. | lld:pubmed |
| pubmed-article:19357261 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19357261 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:19357261 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19357261 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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