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pubmed-article:19352137pubmed:abstractTextThirty-four patients treated concomitantly with lopinavir/ritonavir and rifampicin were evaluated. Overall, only 15% used the recommended increased dose of lopinavir/ritonavir. Of patients on a nonadjusted dose of lopinavir/ritonavir, 67% had a subtherapeutic lopinavir plasma concentration and 38% had a detectable viral load. Forty percent of patients on an increased dose of lopinavir/ritonavir prematurely stopped the drug combination because of adverse events. Combined use of lopinavir/ritonavir and rifampicin is challenging as it implies balancing between suboptimal efficacy and toxicity.lld:pubmed
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pubmed-article:19352137pubmed:articleTitleClinical experience with the combined use of lopinavir/ritonavir and rifampicin.lld:pubmed
pubmed-article:19352137pubmed:affiliationDepartment of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands.lld:pubmed
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