| pubmed-article:19351592 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19351592 | lifeskim:mentions | umls-concept:C0052441 | lld:lifeskim |
| pubmed-article:19351592 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:19351592 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:19351592 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:19351592 | lifeskim:mentions | umls-concept:C0005052 | lld:lifeskim |
| pubmed-article:19351592 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:19351592 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:19351592 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19351592 | pubmed:dateCreated | 2009-4-8 | lld:pubmed |
| pubmed-article:19351592 | pubmed:abstractText | We have investigated the effect of benzo[a]pyrene (B[a]P), a carcinogen of tobacco smoke and an agonist for the aryl hydrocarbon receptor (AHR), on hypoxia-induced angiogenesis. Ischemia was induced by femoral artery ligation in wild-type and AHR-null mice, and the animals were subjected to oral administration of B[a]P (125 mg/kg) once a week. Exposure to B[a]P up-regulated the expression of metallothionein in the ischemic hindlimb and markedly inhibited ischemia-induced angiogenesis in wild-type mice. The amounts of interleukin-6 and of vascular endothelial growth factor (VEGF) mRNA in the ischemic hindlimb of wild-type mice were reduced by exposure to B[a]P. These various effects of B[a]P were markedly attenuated in AHR-null mice. Our observations suggest that the loss of the inhibitory effect of B[a]P on ischemia-induced angiogenesis apparent in AHR-null mice may be attributable to maintenance of interleukin-6 expression and consequent promotion of angiogenesis through up-regulation of VEGF expression. | lld:pubmed |
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| pubmed-article:19351592 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19351592 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19351592 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19351592 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19351592 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:19351592 | pubmed:author | pubmed-author:NakajimaTamie... | lld:pubmed |
| pubmed-article:19351592 | pubmed:author | pubmed-author:GonzalezFrank... | lld:pubmed |
| pubmed-article:19351592 | pubmed:author | pubmed-author:YamadaYoshiji... | lld:pubmed |
| pubmed-article:19351592 | pubmed:author | pubmed-author:MuroharaToyoa... | lld:pubmed |
| pubmed-article:19351592 | pubmed:author | pubmed-author:IchiharaGakuG | lld:pubmed |
| pubmed-article:19351592 | pubmed:author | pubmed-author:IchiharaSahok... | lld:pubmed |
| pubmed-article:19351592 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19351592 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:19351592 | pubmed:volume | 381 | lld:pubmed |
| pubmed-article:19351592 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19351592 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19351592 | pubmed:pagination | 44-9 | lld:pubmed |
| pubmed-article:19351592 | pubmed:dateRevised | 2010-9-24 | lld:pubmed |
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| pubmed-article:19351592 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19351592 | pubmed:articleTitle | Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor. | lld:pubmed |
| pubmed-article:19351592 | pubmed:affiliation | Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurimamachiya-cho, Tsu, Mie 514-8507, Japan. saho@gene.mie-u.ac.jp | lld:pubmed |
