| pubmed-article:19344510 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19344510 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:19344510 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:19344510 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
| pubmed-article:19344510 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:19344510 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:19344510 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:19344510 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19344510 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:19344510 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:19344510 | lifeskim:mentions | umls-concept:C0812229 | lld:lifeskim |
| pubmed-article:19344510 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:19344510 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19344510 | pubmed:dateCreated | 2009-6-2 | lld:pubmed |
| pubmed-article:19344510 | pubmed:abstractText | The tumour-suppressive effects of transforming growth factor-beta (TGF-beta) are well documented; however, the mechanistic basis of these effects is not fully understood. Previously, we showed that a non-canonical member of the Wingless-related protein family, Wnt5a, is required for TGF-beta-mediated effects on mammary development. Several lines of evidence support the hypothesis that Wnt5a acts as a tumour suppressor. In addition, it has been shown that Wnt5a can antagonise canonical Wnt/beta-catenin signalling in various cell types. Here we test the hypothesis that TGF-beta and Wnt5a can antagonise Wnt/beta-catenin signalling and redirect mammary tumour phenotype. The results provide a new mechanism for the tumour-suppressive effects of TGF-beta. | lld:pubmed |
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| pubmed-article:19344510 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19344510 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19344510 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19344510 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19344510 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19344510 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19344510 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19344510 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19344510 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19344510 | pubmed:issn | 1465-542X | lld:pubmed |
| pubmed-article:19344510 | pubmed:author | pubmed-author:FrostAndra... | lld:pubmed |
| pubmed-article:19344510 | pubmed:author | pubmed-author:SerraRosaR | lld:pubmed |
| pubmed-article:19344510 | pubmed:author | pubmed-author:CrowleyMichae... | lld:pubmed |
| pubmed-article:19344510 | pubmed:author | pubmed-author:RoartyKevinK | lld:pubmed |
| pubmed-article:19344510 | pubmed:author | pubmed-author:BaxleySarah... | lld:pubmed |
| pubmed-article:19344510 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19344510 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:19344510 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19344510 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19344510 | pubmed:pagination | R19 | lld:pubmed |
| pubmed-article:19344510 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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