| pubmed-article:19342648 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19342648 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:19342648 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:19342648 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:19342648 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:19342648 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:19342648 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:19342648 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:19342648 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:19342648 | pubmed:dateCreated | 2009-4-3 | lld:pubmed |
| pubmed-article:19342648 | pubmed:abstractText | Posttranslational modification of proteins, such as glycosylation, can impact cell signaling and function. ST6Gal I, a glycosyltransferase expressed by B cells, catalyzes the addition of alpha-2,6 sialic acid to galactose, a modification found on N-linked glycoproteins such as CD22, a negative regulator of B cell activation. We show that SNA lectin, which binds alpha-2,6 sialic acid linked to galactose, shows high binding on plasma blasts and germinal center B cells following viral infection, suggesting ST6Gal I expression remains high on activated B cells in vivo. To understand the relevance of this modification on the antiviral B cell immune response, we infected ST6Gal I(-/-) mice with influenza A/HKx31. We demonstrate that the loss of ST6Gal I expression results in similar influenza infectivity in the lung, but significantly reduced early influenza-specific IgM and IgG levels in the serum, as well as significantly reduced numbers of early viral-specific Ab-secreting cells. At later memory time points, ST6Gal I(-/-) mice show comparable numbers of IgG influenza-specific memory B cells and long-lived plasma cells, with similarly high antiviral IgG titers, with the exception of IgG2c. Finally, we adoptively transfer purified B cells from wild-type or ST6Gal I(-/-) mice into B cell-deficient (microMT(-/-)) mice. Recipient mice that received ST6Gal I(-/-) B cells demonstrated reduced influenza-specific IgM levels, but similar levels of influenza-specific IgG, compared with mice that received wild-type B cells. These data suggest that a B cell intrinsic defect partially contributes to the impaired antiviral humoral response. | lld:pubmed |
| pubmed-article:19342648 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19342648 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19342648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19342648 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19342648 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19342648 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:19342648 | pubmed:author | pubmed-author:JooHye MeeHM | lld:pubmed |
| pubmed-article:19342648 | pubmed:author | pubmed-author:OnamiThandi... | lld:pubmed |
| pubmed-article:19342648 | pubmed:author | pubmed-author:RajiniBheemre... | lld:pubmed |
| pubmed-article:19342648 | pubmed:author | pubmed-author:SangsterMark... | lld:pubmed |
| pubmed-article:19342648 | pubmed:author | pubmed-author:ZengJunweiJ | lld:pubmed |
| pubmed-article:19342648 | pubmed:author | pubmed-author:WrammertJens... | lld:pubmed |
| pubmed-article:19342648 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19342648 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19342648 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:19342648 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19342648 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19342648 | pubmed:pagination | 4721-7 | lld:pubmed |
| pubmed-article:19342648 | pubmed:dateRevised | 2010-9-23 | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:meshHeading | pubmed-meshheading:19342648... | lld:pubmed |
| pubmed-article:19342648 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19342648 | pubmed:articleTitle | The generation of influenza-specific humoral responses is impaired in ST6Gal I-deficient mice. | lld:pubmed |
| pubmed-article:19342648 | pubmed:affiliation | Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA. | lld:pubmed |
| pubmed-article:19342648 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19342648 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19342648 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:16019 | entrezgene:pubmed | pubmed-article:19342648 | lld:entrezgene |
| entrez-gene:20440 | entrezgene:pubmed | pubmed-article:19342648 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19342648 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19342648 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19342648 | lld:pubmed |
