| pubmed-article:19339694 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19339694 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:19339694 | lifeskim:mentions | umls-concept:C0282553 | lld:lifeskim |
| pubmed-article:19339694 | lifeskim:mentions | umls-concept:C1622501 | lld:lifeskim |
| pubmed-article:19339694 | lifeskim:mentions | umls-concept:C0100748 | lld:lifeskim |
| pubmed-article:19339694 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:19339694 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:19339694 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:19339694 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19339694 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:19339694 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:19339694 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:19339694 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:19339694 | pubmed:dateCreated | 2009-6-5 | lld:pubmed |
| pubmed-article:19339694 | pubmed:abstractText | Activin A is a dimeric protein, member of the transforming growth factor (TGF)-beta family that plays a crucial role in wound repair and in fetal tolerance. Emerging evidence also proposes activin A as a key mediator in inflammation. This study reports that activin A induces the directional migration of immature myeloid dendritic cells (iDCs) through the activation of ALK4 and ActRIIA receptor chains. Conversely, activin A was not active on plasmacytoid dendritic cells (DCs) or mature myeloid DCs. iDC migration to activin A was phosphatidylinositol 3-kinase gamma-dependent, Bordetella pertussis toxin- and cycloheximide-sensitive, and was inhibited by M3, a viral-encoded chemokine-binding protein. In a real-time video microscopy-based migration assay, activin A induced polarization of iDCs, but not migration. These characteristics clearly differentiated the chemotactic activities of activin A from TGF-beta and classic chemokines. By the use of combined pharmacologic and low-density microarray analysis, it was possible to define that activin-A-induced migration depends on the selective and polarized release of 2 chemokines, namely CXC chemokine ligands 12 and 14. This study extends the proinflammatory role of activin A to DC recruitment and provides a cautionary message about the reliability of the in vitro chemotaxis assays in discriminating direct versus indirect chemotactic agonists. | lld:pubmed |
| pubmed-article:19339694 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19339694 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19339694 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19339694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19339694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19339694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19339694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19339694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19339694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19339694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19339694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19339694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19339694 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19339694 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19339694 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:19339694 | pubmed:author | pubmed-author:LocatiMassimo... | lld:pubmed |
| pubmed-article:19339694 | pubmed:author | pubmed-author:SozzaniSilvan... | lld:pubmed |
| pubmed-article:19339694 | pubmed:author | pubmed-author:JalaVenkatakr... | lld:pubmed |
| pubmed-article:19339694 | pubmed:author | pubmed-author:HaribabuBoddu... | lld:pubmed |
| pubmed-article:19339694 | pubmed:author | pubmed-author:BosisioDaniel... | lld:pubmed |
| pubmed-article:19339694 | pubmed:author | pubmed-author:MiroloMassimi... | lld:pubmed |
| pubmed-article:19339694 | pubmed:author | pubmed-author:MussoTizianaT | lld:pubmed |
| pubmed-article:19339694 | pubmed:author | pubmed-author:SalogniLauraL | lld:pubmed |
| pubmed-article:19339694 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19339694 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:19339694 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:19339694 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19339694 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19339694 | pubmed:pagination | 5848-56 | lld:pubmed |
| pubmed-article:19339694 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:19339694 | pubmed:meshHeading | pubmed-meshheading:19339694... | lld:pubmed |
| pubmed-article:19339694 | pubmed:meshHeading | pubmed-meshheading:19339694... | lld:pubmed |
| pubmed-article:19339694 | pubmed:meshHeading | pubmed-meshheading:19339694... | lld:pubmed |
| pubmed-article:19339694 | pubmed:meshHeading | pubmed-meshheading:19339694... | lld:pubmed |
| pubmed-article:19339694 | pubmed:meshHeading | pubmed-meshheading:19339694... | lld:pubmed |
| pubmed-article:19339694 | pubmed:meshHeading | pubmed-meshheading:19339694... | lld:pubmed |
| pubmed-article:19339694 | pubmed:meshHeading | pubmed-meshheading:19339694... | lld:pubmed |
| pubmed-article:19339694 | pubmed:meshHeading | pubmed-meshheading:19339694... | lld:pubmed |
| pubmed-article:19339694 | pubmed:meshHeading | pubmed-meshheading:19339694... | lld:pubmed |
| pubmed-article:19339694 | pubmed:meshHeading | pubmed-meshheading:19339694... | lld:pubmed |
| pubmed-article:19339694 | pubmed:meshHeading | pubmed-meshheading:19339694... | lld:pubmed |
| pubmed-article:19339694 | pubmed:meshHeading | pubmed-meshheading:19339694... | lld:pubmed |
| pubmed-article:19339694 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19339694 | pubmed:articleTitle | Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14. | lld:pubmed |
| pubmed-article:19339694 | pubmed:affiliation | Department of Biomedical Sciences and Biotechnology, Section of General Pathology and Immunology, University of Brescia, Brescia, Italy. | lld:pubmed |
| pubmed-article:19339694 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19339694 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:6387 | entrezgene:pubmed | pubmed-article:19339694 | lld:entrezgene |
| entrez-gene:9547 | entrezgene:pubmed | pubmed-article:19339694 | lld:entrezgene |
| entrez-gene:20315 | entrezgene:pubmed | pubmed-article:19339694 | lld:entrezgene |
| entrez-gene:30955 | entrezgene:pubmed | pubmed-article:19339694 | lld:entrezgene |
| entrez-gene:57266 | entrezgene:pubmed | pubmed-article:19339694 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19339694 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19339694 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19339694 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19339694 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19339694 | lld:pubmed |
