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pubmed-article:1933895pubmed:issue23 Pt 1lld:pubmed
pubmed-article:1933895pubmed:dateCreated1991-12-16lld:pubmed
pubmed-article:1933895pubmed:abstractTextTissue sections of 32 squamous cell carcinomas (SCCs) of the head and neck were investigated for the expression of the epithelium-specific cell adhesion molecule E-cadherin. We found that E-cadherin expression is inversely correlated both with the loss of differentiation of the tumor and with lymph node metastasis. The well-differentiated SCCs expressed E-cadherin, often as strongly as the normal stratified epithelium (12 cases were tested); the moderately differentiated SCCs expressed intermediate amounts of E-cadherin or were heterogeneous (15 cases were analyzed); whereas the poorly differentiated SCCs were all E-cadherin-negative (five cases were investigated). Furthermore, seven of eight infiltrated lymph nodes of SCCs were E-cadherin-negative. These data indicate that the loss of the cell adhesion molecule E-cadherin in fact plays an important role in the progression of human squamous cell carcinomas, i.e., that down-regulation of expression is associated with dedifferentiation and metastasis of the tumor cells in vivo.lld:pubmed
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pubmed-article:1933895pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:1933895pubmed:articleTitleE-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis.lld:pubmed
pubmed-article:1933895pubmed:affiliationInstitut für Zellbiologie (Tumorforschung), Medical School, University of Essen, Germany.lld:pubmed
pubmed-article:1933895pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1933895pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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