pubmed-article:1933895 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:1933895 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
pubmed-article:1933895 | lifeskim:mentions | umls-concept:C0042172 | lld:lifeskim |
pubmed-article:1933895 | lifeskim:mentions | umls-concept:C0024204 | lld:lifeskim |
pubmed-article:1933895 | lifeskim:mentions | umls-concept:C0007137 | lld:lifeskim |
pubmed-article:1933895 | lifeskim:mentions | umls-concept:C1168401 | lld:lifeskim |
pubmed-article:1933895 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
pubmed-article:1933895 | lifeskim:mentions | umls-concept:C2248595 | lld:lifeskim |
pubmed-article:1933895 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:1933895 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
pubmed-article:1933895 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:1933895 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:1933895 | pubmed:issue | 23 Pt 1 | lld:pubmed |
pubmed-article:1933895 | pubmed:dateCreated | 1991-12-16 | lld:pubmed |
pubmed-article:1933895 | pubmed:abstractText | Tissue sections of 32 squamous cell carcinomas (SCCs) of the head and neck were investigated for the expression of the epithelium-specific cell adhesion molecule E-cadherin. We found that E-cadherin expression is inversely correlated both with the loss of differentiation of the tumor and with lymph node metastasis. The well-differentiated SCCs expressed E-cadherin, often as strongly as the normal stratified epithelium (12 cases were tested); the moderately differentiated SCCs expressed intermediate amounts of E-cadherin or were heterogeneous (15 cases were analyzed); whereas the poorly differentiated SCCs were all E-cadherin-negative (five cases were investigated). Furthermore, seven of eight infiltrated lymph nodes of SCCs were E-cadherin-negative. These data indicate that the loss of the cell adhesion molecule E-cadherin in fact plays an important role in the progression of human squamous cell carcinomas, i.e., that down-regulation of expression is associated with dedifferentiation and metastasis of the tumor cells in vivo. | lld:pubmed |
pubmed-article:1933895 | pubmed:language | eng | lld:pubmed |
pubmed-article:1933895 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1933895 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:1933895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1933895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1933895 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:1933895 | pubmed:month | Dec | lld:pubmed |
pubmed-article:1933895 | pubmed:issn | 0008-5472 | lld:pubmed |
pubmed-article:1933895 | pubmed:author | pubmed-author:UngerAA | lld:pubmed |
pubmed-article:1933895 | pubmed:author | pubmed-author:JahnkeKK | lld:pubmed |
pubmed-article:1933895 | pubmed:author | pubmed-author:BirchmeierWW | lld:pubmed |
pubmed-article:1933895 | pubmed:author | pubmed-author:BehrensJJ | lld:pubmed |
pubmed-article:1933895 | pubmed:author | pubmed-author:FrixenU HUH | lld:pubmed |
pubmed-article:1933895 | pubmed:author | pubmed-author:SchipperJ HJH | lld:pubmed |
pubmed-article:1933895 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:1933895 | pubmed:day | 1 | lld:pubmed |
pubmed-article:1933895 | pubmed:volume | 51 | lld:pubmed |
pubmed-article:1933895 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:1933895 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:1933895 | pubmed:pagination | 6328-37 | lld:pubmed |
pubmed-article:1933895 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:meshHeading | pubmed-meshheading:1933895-... | lld:pubmed |
pubmed-article:1933895 | pubmed:year | 1991 | lld:pubmed |
pubmed-article:1933895 | pubmed:articleTitle | E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. | lld:pubmed |
pubmed-article:1933895 | pubmed:affiliation | Institut für Zellbiologie (Tumorforschung), Medical School, University of Essen, Germany. | lld:pubmed |
pubmed-article:1933895 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:1933895 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1933895 | lld:pubmed |