pubmed-article:19335537 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:19335537 | lifeskim:mentions | umls-concept:C0175677 | lld:lifeskim |
pubmed-article:19335537 | lifeskim:mentions | umls-concept:C0017070 | lld:lifeskim |
pubmed-article:19335537 | lifeskim:mentions | umls-concept:C2610216 | lld:lifeskim |
pubmed-article:19335537 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
pubmed-article:19335537 | lifeskim:mentions | umls-concept:C0536942 | lld:lifeskim |
pubmed-article:19335537 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:19335537 | pubmed:dateCreated | 2009-4-1 | lld:pubmed |
pubmed-article:19335537 | pubmed:abstractText | Human immunodeficiency virus (HIV)-associated sensory neuropathy (HIV-SN) occurs in a large fraction of patients infected with HIV. Viral components, including the coat protein gp120, are thought to exert toxic actions on dorsal root ganglia (DRG) sensory neurons that can be further exacerbated by treatment of HIV infection with some antiretroviral agents. In a tissue culture model of HIV-SN, we found that gp120-induced axonal degeneration in DRG sensory neurons was prevented by treatment with the immunophilin ligand GPI-1046. Gp120 induced a rapid and large release of endoplasmic reticulum (ER) calcium in DRG neurons that was attenuated by treatment with GPI-1046. Further experiments suggested that GPI-1046 reduced the total ER calcium load by attenuating store-operated calcium (SOC) entry. Together, these results suggest that GPI-1046 protects DRG from gp120-induced axonal damage by decreasing the entry of calcium through SOC, thus reducing the total volume of ER calcium that is available to be released by gp120. | lld:pubmed |
pubmed-article:19335537 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:language | eng | lld:pubmed |
pubmed-article:19335537 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:19335537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19335537 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:19335537 | pubmed:month | Mar | lld:pubmed |
pubmed-article:19335537 | pubmed:issn | 1529-8027 | lld:pubmed |
pubmed-article:19335537 | pubmed:author | pubmed-author:MorrisMichael... | lld:pubmed |
pubmed-article:19335537 | pubmed:author | pubmed-author:HaugheyNorman... | lld:pubmed |
pubmed-article:19335537 | pubmed:author | pubmed-author:HökeAhmetA | lld:pubmed |
pubmed-article:19335537 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:19335537 | pubmed:volume | 14 | lld:pubmed |
pubmed-article:19335537 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:19335537 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:19335537 | pubmed:pagination | 27-35 | lld:pubmed |
pubmed-article:19335537 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
pubmed-article:19335537 | pubmed:meshHeading | pubmed-meshheading:19335537... | lld:pubmed |
pubmed-article:19335537 | pubmed:meshHeading | pubmed-meshheading:19335537... | lld:pubmed |
pubmed-article:19335537 | pubmed:meshHeading | pubmed-meshheading:19335537... | lld:pubmed |
pubmed-article:19335537 | pubmed:meshHeading | pubmed-meshheading:19335537... | lld:pubmed |
pubmed-article:19335537 | pubmed:meshHeading | pubmed-meshheading:19335537... | lld:pubmed |
pubmed-article:19335537 | pubmed:meshHeading | pubmed-meshheading:19335537... | lld:pubmed |
pubmed-article:19335537 | pubmed:meshHeading | pubmed-meshheading:19335537... | lld:pubmed |
pubmed-article:19335537 | pubmed:meshHeading | pubmed-meshheading:19335537... | lld:pubmed |
pubmed-article:19335537 | pubmed:meshHeading | pubmed-meshheading:19335537... | lld:pubmed |
pubmed-article:19335537 | pubmed:meshHeading | pubmed-meshheading:19335537... | lld:pubmed |
pubmed-article:19335537 | pubmed:meshHeading | pubmed-meshheading:19335537... | lld:pubmed |