| pubmed-article:19332500 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19332500 | lifeskim:mentions | umls-concept:C0104230 | lld:lifeskim |
| pubmed-article:19332500 | lifeskim:mentions | umls-concept:C1571481 | lld:lifeskim |
| pubmed-article:19332500 | lifeskim:mentions | umls-concept:C0023693 | lld:lifeskim |
| pubmed-article:19332500 | lifeskim:mentions | umls-concept:C0237452 | lld:lifeskim |
| pubmed-article:19332500 | lifeskim:mentions | umls-concept:C0439590 | lld:lifeskim |
| pubmed-article:19332500 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19332500 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19332500 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:19332500 | pubmed:issue | Pt 11 | lld:pubmed |
| pubmed-article:19332500 | pubmed:dateCreated | 2009-6-1 | lld:pubmed |
| pubmed-article:19332500 | pubmed:abstractText | Light adaptation in vertebrate photoreceptors is mediated by multiple mechanisms, one of which could involve nuclear feedback and changes in gene expression. Therefore, we have investigated light adaptation-associated changes in gene expression using microarrays and real-time PCR in isolated photoreceptors, in cultured isolated retinas and in acutely isolated retinas. In all three preparations after 2 h of an exposure to a bright light, we observed an up-regulation of almost 100% of three genes, Sag, Guca1a and Guca1b, coding for proteins known to play a major role in phototransduction: arrestin, GCAP1 and GCAP2. No detectable up-regulation occurred for light exposures of less than 1 h. Functional in vivo electroretinographic tests show that a partial recovery of the dark current occurred 1-2 h after prolonged illumination with a steady light that initially caused a substantial suppression of the photoresponse. These observations demonstrate that prolonged illumination results in the up-regulation of genes coding for proteins involved in the phototransduction signalling cascade, possibly underlying a novel component of light adaptation occurring 1-2 h after the onset of a steady bright light. | lld:pubmed |
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| pubmed-article:19332500 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19332500 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19332500 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19332500 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19332500 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19332500 | pubmed:issn | 1469-7793 | lld:pubmed |
| pubmed-article:19332500 | pubmed:author | pubmed-author:TorreVincentV | lld:pubmed |
| pubmed-article:19332500 | pubmed:author | pubmed-author:CervettoLuigi... | lld:pubmed |
| pubmed-article:19332500 | pubmed:author | pubmed-author:GarginiClaudi... | lld:pubmed |
| pubmed-article:19332500 | pubmed:author | pubmed-author:LiveseyFreder... | lld:pubmed |
| pubmed-article:19332500 | pubmed:author | pubmed-author:CodegaPaoloP | lld:pubmed |
| pubmed-article:19332500 | pubmed:author | pubmed-author:Subkhankulova... | lld:pubmed |
| pubmed-article:19332500 | pubmed:author | pubmed-author:Della... | lld:pubmed |
| pubmed-article:19332500 | pubmed:author | pubmed-author:BedollaDiana... | lld:pubmed |
| pubmed-article:19332500 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19332500 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19332500 | pubmed:volume | 587 | lld:pubmed |
| pubmed-article:19332500 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19332500 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19332500 | pubmed:pagination | 2457-72 | lld:pubmed |
