| pubmed-article:19307759 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19307759 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:19307759 | lifeskim:mentions | umls-concept:C0318198 | lld:lifeskim |
| pubmed-article:19307759 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:19307759 | lifeskim:mentions | umls-concept:C0017362 | lld:lifeskim |
| pubmed-article:19307759 | lifeskim:mentions | umls-concept:C0598079 | lld:lifeskim |
| pubmed-article:19307759 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:19307759 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:19307759 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19307759 | pubmed:dateCreated | 2009-3-24 | lld:pubmed |
| pubmed-article:19307759 | pubmed:abstractText | Sequencing analysis of a 5-kb DNA fragment from Streptomyces venezuelae ATCC 15439 revealed the presence of one 3.1-kb open reading frame (ORF), designated afsRsv. The deduced product of afsR-sv (1,056 aa) was found to have high homology with the global regulatory protein AfsR. Homology-based analysis showed that afsR-sv represents a transcriptional activator belonging to the Streptomyces antibiotic regulatory protein (SARP) family that includes an Nterminal SARP domain containing a bacterial transcriptional activation domain (BTAD), an NB-ARC domain, and a Cterminal tetratricopeptide repeat domain. Gene expression analysis by reverse transcriptase PCR (RT-PCR) demonstrated the activation of transcription of genes belonging to pikromycin production, when afsR-sv was overexpressed in S. venezuelae. Heterologous expression of the afsR-sv in different Streptomyces strains resulted in increased production of the respective antibiotics, suggesting that afsR-sv is a positive regulator of antibiotics biosynthesis. | lld:pubmed |
| pubmed-article:19307759 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19307759 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19307759 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19307759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19307759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19307759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19307759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19307759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19307759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19307759 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19307759 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19307759 | pubmed:issn | 1017-7825 | lld:pubmed |
| pubmed-article:19307759 | pubmed:author | pubmed-author:SohngJae... | lld:pubmed |
| pubmed-article:19307759 | pubmed:author | pubmed-author:LeeHei ChanHC | lld:pubmed |
| pubmed-article:19307759 | pubmed:author | pubmed-author:OhTae-JinTJ | lld:pubmed |
| pubmed-article:19307759 | pubmed:author | pubmed-author:MaharjanSushi... | lld:pubmed |
| pubmed-article:19307759 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19307759 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:19307759 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19307759 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19307759 | pubmed:pagination | 121-7 | lld:pubmed |
| pubmed-article:19307759 | pubmed:meshHeading | pubmed-meshheading:19307759... | lld:pubmed |
| pubmed-article:19307759 | pubmed:meshHeading | pubmed-meshheading:19307759... | lld:pubmed |
| pubmed-article:19307759 | pubmed:meshHeading | pubmed-meshheading:19307759... | lld:pubmed |
| pubmed-article:19307759 | pubmed:meshHeading | pubmed-meshheading:19307759... | lld:pubmed |
| pubmed-article:19307759 | pubmed:meshHeading | pubmed-meshheading:19307759... | lld:pubmed |
| pubmed-article:19307759 | pubmed:meshHeading | pubmed-meshheading:19307759... | lld:pubmed |
| pubmed-article:19307759 | pubmed:meshHeading | pubmed-meshheading:19307759... | lld:pubmed |
| pubmed-article:19307759 | pubmed:meshHeading | pubmed-meshheading:19307759... | lld:pubmed |
| pubmed-article:19307759 | pubmed:meshHeading | pubmed-meshheading:19307759... | lld:pubmed |
| pubmed-article:19307759 | pubmed:meshHeading | pubmed-meshheading:19307759... | lld:pubmed |
| pubmed-article:19307759 | pubmed:meshHeading | pubmed-meshheading:19307759... | lld:pubmed |
| pubmed-article:19307759 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19307759 | pubmed:articleTitle | Identification and functional characterization of an afsR homolog regulatory gene from Streptomyces venezuelae ATCC 15439. | lld:pubmed |
| pubmed-article:19307759 | pubmed:affiliation | Department of Pharmaceutical Engineering, SunMoon University, Asansi 336-708, Korea. | lld:pubmed |
| pubmed-article:19307759 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19307759 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19307759 | lld:entrezgene |
