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pubmed-article:19307542pubmed:abstractTextThe autosomal recessive disorder Niemannn-Pick type C (NPC) presents in adulthood with psychosis or cognitive deficits associated with supranuclear gaze palsies. While saccadic innervation to the extraocular muscles is generated in the brainstem, the frontal lobes play an integral role in the initiation of volitional saccades and the suppression of unwanted reflexive saccades. No study has examined the frontally driven volitional control of saccadic eye movements in NPC.lld:pubmed
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pubmed-article:19307542pubmed:articleTitleSaccades in adult Niemann-Pick disease type C reflect frontal, brainstem, and biochemical deficits.lld:pubmed
pubmed-article:19307542pubmed:affiliationDepartment of Optometry and Vision Sciences, University of Melbourne, Parkville, Australia.lld:pubmed
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