| pubmed-article:19295630 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19295630 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:19295630 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:19295630 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19295630 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19295630 | pubmed:dateCreated | 2009-3-19 | lld:pubmed |
| pubmed-article:19295630 | pubmed:abstractText | An important function of receptors that signal through immunoreceptor tyrosine-based activation motifs (ITAMs) is to regulate signaling by heterologous receptors. This review describes mechanisms by which ITAM-associated receptors modulate signaling by Toll-like receptors (TLRs), tumor necrosis factor receptor family members and cytokine receptors that use the Jak-STAT signaling pathway, and the biological importance of this signal transduction cross-talk. ITAM-mediated cross-regulation can either augment or dampen signaling by other receptors. Conversely, TLRs and cytokines modulate ITAM-mediated signaling, by means including activation of beta2 integrins that are coupled to the ITAM-containing adaptors DAP12 and FcRgamma. Integration of ITAM signaling into signaling networks through cross-talk with other signal transduction pathways results in tight regulation and fine tuning of cellular responses to various extracellular stimuli and contributes to induction of specific activation and differentiation pathways. | lld:pubmed |
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