| pubmed-article:19295128 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19295128 | lifeskim:mentions | umls-concept:C0013963 | lld:lifeskim |
| pubmed-article:19295128 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:19295128 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:19295128 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19295128 | pubmed:issue | Pt 7 | lld:pubmed |
| pubmed-article:19295128 | pubmed:dateCreated | 2009-3-19 | lld:pubmed |
| pubmed-article:19295128 | pubmed:abstractText | Functional loss of the cell-cell adhesion molecule E-cadherin is an essential event for epithelial-mesenchymal transition (EMT), a process that allows cell migration during embryonic development and tumour invasion. In most carcinomas, transcriptional repression has emerged as the main mechanism responsible for E-cadherin downregulation. Here, we report the identification of class I bHLH factor E2-2 (TCF4/ITF2) as a new EMT regulator. Both isoforms of E2-2 (E2-2A and E2-2B) induce a full EMT when overexpressed in MDCK cells but without affecting the tumorigenic properties of parental cells, in contrast to other EMT inducers, such as Snail1 or class I bHLH E47. E-cadherin repression mediated by E2-2 is indirect and independent of proximal E-boxes of the promoter. Knockdown studies indicate that E2-2 expression is dispensable for maintenance of the EMT driven by Snail1 and E47. Comparative gene-profiling analysis reveals that E2-2 factors induce similar, yet distinct, genetic programs to that induced by E47 in MDCK cells. These results, together with the embryonic expression pattern of Tcf4 and E2A (which encodes E12/E47), support a distinct role for E2-2 and suggest an interesting interplay between E-cadherin repressors in the regulation of physiological and pathological EMT processes. | lld:pubmed |
| pubmed-article:19295128 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19295128 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19295128 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19295128 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19295128 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19295128 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19295128 | pubmed:issn | 0021-9533 | lld:pubmed |
| pubmed-article:19295128 | pubmed:author | pubmed-author:NietoM... | lld:pubmed |
| pubmed-article:19295128 | pubmed:author | pubmed-author:Moreno-BuenoG... | lld:pubmed |
| pubmed-article:19295128 | pubmed:author | pubmed-author:CanoAmparoA | lld:pubmed |
| pubmed-article:19295128 | pubmed:author | pubmed-author:SobradoVeróni... | lld:pubmed |
| pubmed-article:19295128 | pubmed:author | pubmed-author:CubilloEvaE | lld:pubmed |
| pubmed-article:19295128 | pubmed:author | pubmed-author:PortilloFranc... | lld:pubmed |
| pubmed-article:19295128 | pubmed:author | pubmed-author:HoltLiam JLJ | lld:pubmed |
| pubmed-article:19295128 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19295128 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19295128 | pubmed:volume | 122 | lld:pubmed |
| pubmed-article:19295128 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19295128 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19295128 | pubmed:pagination | 1014-24 | lld:pubmed |
| pubmed-article:19295128 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:19295128 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19295128 | pubmed:articleTitle | The class I bHLH factors E2-2A and E2-2B regulate EMT. | lld:pubmed |
| pubmed-article:19295128 | pubmed:affiliation | Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029 Madrid, Spain. | lld:pubmed |
| pubmed-article:19295128 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19295128 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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