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pubmed-article:19284605pubmed:abstractTextHigh-risk neuroblastoma has an overall five-year survival of less than 40%, indicating a need for new treatment strategies such as angiogenesis inhibition. Recent studies have shown that chemotherapeutic drugs can inhibit angiogenesis if administered in a continuous schedule. The aim of this study was primarily to characterize tumor spread in an orthotopic, metastatic model for aggressive, MYCN-amplified neuroblastoma and secondarily to study the effects of daily administration of the chemotherapeutic agent CHS 828 on tumor angiogenesis, tumor growth, and spread.lld:pubmed
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pubmed-article:19284605pubmed:articleTitleRegression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments.lld:pubmed
pubmed-article:19284605pubmed:affiliationDepartment of Medical Cell Biology, Uppsala University, 75123 Uppsala, Sweden. dieter.fuchs@mcb.uu.selld:pubmed
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pubmed-article:19284605pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed