| pubmed-article:19284538 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:19284538 | lifeskim:mentions | umls-concept:C0376452 | lld:lifeskim |
| pubmed-article:19284538 | lifeskim:mentions | umls-concept:C0750572 | lld:lifeskim |
| pubmed-article:19284538 | lifeskim:mentions | umls-concept:C1510992 | lld:lifeskim |
| pubmed-article:19284538 | lifeskim:mentions | umls-concept:C1999230 | lld:lifeskim |
| pubmed-article:19284538 | lifeskim:mentions | umls-concept:C2349200 | lld:lifeskim |
| pubmed-article:19284538 | lifeskim:mentions | umls-concept:C0443131 | lld:lifeskim |
| pubmed-article:19284538 | lifeskim:mentions | umls-concept:C1709595 | lld:lifeskim |
| pubmed-article:19284538 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19284538 | pubmed:dateCreated | 2009-3-20 | lld:pubmed |
| pubmed-article:19284538 | pubmed:abstractText | DNA methylation plays a vital role in normal cellular function, with aberrant methylation signatures being implicated in a growing number of human pathologies and complex human traits. Methods based on the modification of genomic DNA with sodium bisulfite are considered the 'gold-standard' for DNA methylation profiling on genomic DNA; however, they require relatively large amounts of DNA and may be prohibitively expensive when used on the large sample sizes necessary to detect small effects. We propose that a high-throughput DNA pooling approach will facilitate the use of emerging methylomic profiling techniques in large samples. | lld:pubmed |
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| pubmed-article:19284538 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19284538 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19284538 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:19284538 | pubmed:issn | 1756-8935 | lld:pubmed |
| pubmed-article:19284538 | pubmed:author | pubmed-author:MillJonathanJ | lld:pubmed |
| pubmed-article:19284538 | pubmed:author | pubmed-author:PlominRobertR | lld:pubmed |
| pubmed-article:19284538 | pubmed:author | pubmed-author:HaworthClaire... | lld:pubmed |
| pubmed-article:19284538 | pubmed:author | pubmed-author:DochertySophi... | lld:pubmed |
| pubmed-article:19284538 | pubmed:author | pubmed-author:DavisOliver... | lld:pubmed |
| pubmed-article:19284538 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19284538 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:19284538 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19284538 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19284538 | pubmed:pagination | 3 | lld:pubmed |
| pubmed-article:19284538 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19284538 | pubmed:articleTitle | Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation. | lld:pubmed |
| pubmed-article:19284538 | pubmed:affiliation | Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK. spjgsdo@iop.kcl.ac.uk | lld:pubmed |
| pubmed-article:19284538 | pubmed:publicationType | Journal Article | lld:pubmed |
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