| pubmed-article:19271701 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19271701 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:19271701 | lifeskim:mentions | umls-concept:C0005064 | lld:lifeskim |
| pubmed-article:19271701 | lifeskim:mentions | umls-concept:C0034791 | lld:lifeskim |
| pubmed-article:19271701 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:19271701 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19271701 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:19271701 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:19271701 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:19271701 | pubmed:dateCreated | 2009-4-2 | lld:pubmed |
| pubmed-article:19271701 | pubmed:abstractText | Radiolabeled antagonists of specific peptide receptors identify a higher number of receptor binding sites than agonists and may thus be preferable for in vivo tumor targeting. In this study, two novel radioiodinated 1,4-benzodiazepines, (S)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea (9) and (R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea (7), were developed. They were characterized in vitro as high affinity selective antagonists at cholecystokinin types 1 and 2 (CCK(1) and CCK(2)) receptors using receptor binding, calcium mobilization, and internalization studies. Their binding to human tumor tissues was assessed with in vitro receptor autoradiography and compared with an established peptidic CCK agonist radioligand. The (125)I-labeled CCK(1) receptor-selective compound 9 often revealed a substantially higher amount of CCK(1) receptor binding sites in tumors than the agonist (125)I-CCK. Conversely, the radioiodinated CCK(2) receptor-selective compound 7 showed generally weaker tumor binding than (125)I-CCK. In conclusion, compound 9 is an excellent radioiodinated nonpeptidic antagonist ligand for direct and selective labeling of CCK(1) receptors in vitro. Moreover, it represents a suitable candidate to test antagonist binding to CCK(1) receptor-expressing tumors in vivo. | lld:pubmed |
| pubmed-article:19271701 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19271701 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19271701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19271701 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19271701 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19271701 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:19271701 | pubmed:author | pubmed-author:BøeH AHA | lld:pubmed |
| pubmed-article:19271701 | pubmed:author | pubmed-author:MillerLaurenc... | lld:pubmed |
| pubmed-article:19271701 | pubmed:author | pubmed-author:ReubiJean... | lld:pubmed |
| pubmed-article:19271701 | pubmed:author | pubmed-author:HarikumarKale... | lld:pubmed |
| pubmed-article:19271701 | pubmed:author | pubmed-author:PortoghesePhi... | lld:pubmed |
| pubmed-article:19271701 | pubmed:author | pubmed-author:KörnerMeikeM | lld:pubmed |
| pubmed-article:19271701 | pubmed:author | pubmed-author:WaserBeatrice... | lld:pubmed |
| pubmed-article:19271701 | pubmed:author | pubmed-author:AkgünEyupE | lld:pubmed |
| pubmed-article:19271701 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19271701 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:19271701 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:19271701 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19271701 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19271701 | pubmed:pagination | 2138-47 | lld:pubmed |
| pubmed-article:19271701 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
| pubmed-article:19271701 | pubmed:meshHeading | pubmed-meshheading:19271701... | lld:pubmed |
