| pubmed-article:19267250 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19267250 | lifeskim:mentions | umls-concept:C0025266 | lld:lifeskim |
| pubmed-article:19267250 | lifeskim:mentions | umls-concept:C0001792 | lld:lifeskim |
| pubmed-article:19267250 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:19267250 | lifeskim:mentions | umls-concept:C0006560 | lld:lifeskim |
| pubmed-article:19267250 | lifeskim:mentions | umls-concept:C1954276 | lld:lifeskim |
| pubmed-article:19267250 | lifeskim:mentions | umls-concept:C0439234 | lld:lifeskim |
| pubmed-article:19267250 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:19267250 | pubmed:dateCreated | 2009-8-11 | lld:pubmed |
| pubmed-article:19267250 | pubmed:abstractText | Inflammation is believed to play a role in prostate cancer (PCa) etiology, but it is unclear whether inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6) associate with PCa risk in older men. Using Cox regression, we assessed the relationship between baseline concentrations of CRP and IL-6 and the subsequent PCa risk in the Cardiovascular Health Study, a population-based cohort study of mostly European American men of ages >64 years (n = 2,234; mean follow-up = 8.7 years; 215 incident PCa cases). We also tested associations between CRP and IL-6 tagSNPs and PCa risk, focusing on SNPs that are known to associate with circulating CRP and/or IL-6. Neither CRP nor IL-6 blood concentrations was associated with PCa risk. The C allele of IL-6 SNP rs1800795 (-174), a known functional variant, was associated with increased risk in a dominant model (HR = 1.44; 95% CI = 1.03-2.01; p = 0.03), but was not statistically significant after accounting for multiple tests (permutation p = 0.21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation. | lld:pubmed |
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| pubmed-article:19267250 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19267250 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19267250 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19267250 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19267250 | pubmed:issn | 1573-7225 | lld:pubmed |
| pubmed-article:19267250 | pubmed:author | pubmed-author:ReinerAlexand... | lld:pubmed |
| pubmed-article:19267250 | pubmed:author | pubmed-author:StanfordJanet... | lld:pubmed |
| pubmed-article:19267250 | pubmed:author | pubmed-author:AustinMelissa... | lld:pubmed |
| pubmed-article:19267250 | pubmed:author | pubmed-author:CarlsonChrist... | lld:pubmed |
| pubmed-article:19267250 | pubmed:author | pubmed-author:FitzpatrickAn... | lld:pubmed |
| pubmed-article:19267250 | pubmed:author | pubmed-author:BiggsMary LML | lld:pubmed |
| pubmed-article:19267250 | pubmed:author | pubmed-author:DeCambreMarva... | lld:pubmed |
| pubmed-article:19267250 | pubmed:author | pubmed-author:PierceBrandon... | lld:pubmed |
| pubmed-article:19267250 | pubmed:author | pubmed-author:LiChristopher... | lld:pubmed |
| pubmed-article:19267250 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19267250 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:19267250 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19267250 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19267250 | pubmed:pagination | 1193-203 | lld:pubmed |
| pubmed-article:19267250 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:19267250 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19267250 | pubmed:articleTitle | C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older. | lld:pubmed |
| pubmed-article:19267250 | pubmed:affiliation | Institute for Public Health Genetics, University of Washington, Seattle, WA, USA. bpierce@health.bsd.uchicago.edu | lld:pubmed |
| pubmed-article:19267250 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19267250 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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