| pubmed-article:19265143 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19265143 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19265143 | lifeskim:mentions | umls-concept:C0032854 | lld:lifeskim |
| pubmed-article:19265143 | lifeskim:mentions | umls-concept:C0017355 | lld:lifeskim |
| pubmed-article:19265143 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:19265143 | lifeskim:mentions | umls-concept:C0162832 | lld:lifeskim |
| pubmed-article:19265143 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:19265143 | lifeskim:mentions | umls-concept:C1705822 | lld:lifeskim |
| pubmed-article:19265143 | lifeskim:mentions | umls-concept:C1257986 | lld:lifeskim |
| pubmed-article:19265143 | lifeskim:mentions | umls-concept:C0348011 | lld:lifeskim |
| pubmed-article:19265143 | lifeskim:mentions | umls-concept:C1561558 | lld:lifeskim |
| pubmed-article:19265143 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19265143 | pubmed:dateCreated | 2009-3-6 | lld:pubmed |
| pubmed-article:19265143 | pubmed:abstractText | In vivo data suggest that monocytes participate critically in cross-presentation, but other data suggest that lymph node resident dendritic cells (DCs) mainly cross-present. Here, we utilized a three-dimensional model of a blood vessel wall that endogenously supports DC development from human monocytes, and we incorporated dying autologous cells in the subendothelial matrix of the model. Flu-infected dying cells promoted monocytes to become mature DCs and cross-present cell-associated Ags for the activation of CTLs. Similar responses were induced by loading the dying cells with the TLR7/8 ligand ssRNA, whereas dying cells loaded with TLR3 ligand were less efficient. Monocyte-derived DCs that developed in this model cross-presented Ag to T cells efficiently regardless of whether they engulfed detectable amounts of labeled dying cells. Unexpectedly, the monocyte-derived cells that directly engulfed dying cells in vitro were not the major APCs stimulating CD8(+) lymphocytes. Instead, bystander DCs acquired more robust capacity to cross-prime through receipt of MHC class I/peptide from the phagocytic, monocyte-derived cells. In mice, lymph node-homing monocyte-derived DCs processed Ags from engulfed cells and then transferred MHC class I/peptide complexes to confer cross-priming capacity to MHC class I-deficient lymph node resident CD8alpha(+) DCs. Thus, natural or synthetic TLR7/8 agonists contained within dying cells promote the conversion of monocytes to DCs with capacity for cross-presentation and for "cross-dressing" other DCs. These data reveal a way in which migratory monocyte-derived DCs and other DCs, like lymph node resident DCs, both mediate cross-presentation. | lld:pubmed |
| pubmed-article:19265143 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19265143 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19265143 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19265143 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19265143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19265143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19265143 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19265143 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19265143 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:19265143 | pubmed:author | pubmed-author:MeradMiriamM | lld:pubmed |
| pubmed-article:19265143 | pubmed:author | pubmed-author:NguyenVan... | lld:pubmed |
| pubmed-article:19265143 | pubmed:author | pubmed-author:RandolphGwend... | lld:pubmed |
| pubmed-article:19265143 | pubmed:author | pubmed-author:QuChunfengC | lld:pubmed |
| pubmed-article:19265143 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19265143 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19265143 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:19265143 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19265143 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19265143 | pubmed:pagination | 3650-9 | lld:pubmed |
| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
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| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
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| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
| pubmed-article:19265143 | pubmed:meshHeading | pubmed-meshheading:19265143... | lld:pubmed |
| pubmed-article:19265143 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19265143 | pubmed:articleTitle | MHC class I/peptide transfer between dendritic cells overcomes poor cross-presentation by monocyte-derived APCs that engulf dying cells. | lld:pubmed |
| pubmed-article:19265143 | pubmed:affiliation | Department of Gene and Cell Medicine and Institute for Immunology, Icahn Medical Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. | lld:pubmed |
| pubmed-article:19265143 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19265143 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:19265143 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19265143 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19265143 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19265143 | lld:pubmed |
